August EM - Search Results

1

1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.

Mansuri MM, Starrett JE Jr, Ghazzouli I, Hitchcock MJ, Sterzycki RZ, Brankovan V, Lin TS, August EM, Prusoff WH, Sommadossi JP, et al. Mansuri MM, et al. Among authors: august em. J Med Chem. 1989 Feb;32(2):461-6. doi: 10.1021/jm00122a029. J Med Chem. 1989. PMID: 2536441

2

Synthesis and antiviral activity of several 2,5'-anhydro analogues of 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-azido-2',3'-dideoxy-5-halouridines, and 3'-deoxythymidine against human immunodeficiency virus and Rauscher-murine leukemia virus.

Lin TS, Shen ZY, August EM, Brankovan V, Yang H, Ghazzouli I, Prusoff WH. Lin TS, et al. Among authors: august em. J Med Chem. 1989 Aug;32(8):1891-5. doi: 10.1021/jm00128a034. J Med Chem. 1989. PMID: 2754712

3

3'-Deoxythymidin-2'-ene permeation of human lymphocyte H9 cells by nonfacilitated diffusion.

August EM, Birks EM, Prusoff WH. August EM, et al. Mol Pharmacol. 1991 Feb;39(2):246-9. Mol Pharmacol. 1991. PMID: 1847498

4

Inhibition of poly(adenosine diphosphate-ribose) polymerase by thymidine and thymidine analogues in L1210 cells and its relationship to the potentiation of the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea but not of 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine.

August EM, Cooper DL, Prusoff WH. August EM, et al. Cancer Res. 1991 Mar 15;51(6):1586-90. Cancer Res. 1991. PMID: 1900213

5

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.

Lin TS, Schinazi R, Griffith BP, August EM, Eriksson BF, Zheng DK, Huang LA, Prusoff WH. Lin TS, et al. Among authors: august em. Antimicrob Agents Chemother. 1989 Dec;33(12):2149-51. doi: 10.1128/AAC.33.12.2149. Antimicrob Agents Chemother. 1989. PMID: 2619282 Free PMC article.

6

Effect of thymidine on uptake, DNA alkylation, and DNA repair in L1210 cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea or 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine.

August EM, Prusoff WH. August EM, et al. Cancer Res. 1988 Aug 1;48(15):4272-5. Cancer Res. 1988. PMID: 3390823

7

Effect of 3'-deoxythymidin-2'-ene (d4T) on nucleoside metabolism in H9 cells.

Marongiu ME, August EM, Prusoff WH. Marongiu ME, et al. Among authors: august em. Biochem Pharmacol. 1990 May 15;39(10):1523-8. doi: 10.1016/0006-2952(90)90516-n. Biochem Pharmacol. 1990. PMID: 2159760 Free article.

8

Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4T): a potent and selective inhibitor of human immunodeficiency virus.

August EM, Marongiu ME, Lin TS, Prusoff WH. August EM, et al. Biochem Pharmacol. 1988 Dec 1;37(23):4419-22. doi: 10.1016/0006-2952(88)90655-7. Biochem Pharmacol. 1988. PMID: 2849444 Free article. No abstract available.

9

Metabolism and mode of selective inhibition of human immunodeficiency virus replication by 3'-azido-2',3'-dideoxy-5-iodouridine and 3'-azido-2',3'-dideoxy-5-bromouridine.

August EM, Qian HY, Birks EM, Thombre UA, Lin TS, Prusoff WH. August EM, et al. Biochem Pharmacol. 1993 Jan 7;45(1):223-30. doi: 10.1016/0006-2952(93)90396-e. Biochem Pharmacol. 1993. PMID: 7678740 Free article.

10

Approaches to antiviral drug development.

Prusoff WH, Lin TS, August EM, Wood TG, Marongiu ME. Prusoff WH, et al. Among authors: august em. Yale J Biol Med. 1989 Mar-Apr;62(2):215-25. Yale J Biol Med. 1989. PMID: 2773516 Free PMC article.

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