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Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy.
Mol Ther. 2015 Apr;23(4):757-68. doi: 10.1038/mt.2014.208. Epub 2014 Nov 4.
Mol Ther. 2015.
PMID: 25366031
Free PMC article.
T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia.
Mardiros A, Dos Santos C, McDonald T, Brown CE, Wang X, Budde LE, Hoffman L, Aguilar B, Chang WC, Bretzlaff W, Chang B, Jonnalagadda M, Starr R, Ostberg JR, Jensen MC, Bhatia R, Forman SJ.
Mardiros A, et al. Among authors: bretzlaff w.
Blood. 2013 Oct 31;122(18):3138-48. doi: 10.1182/blood-2012-12-474056. Epub 2013 Sep 12.
Blood. 2013.
PMID: 24030378
Free PMC article.
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Differential influence on antibody dependent cellular phagocytosis by different glycoforms on therapeutic Monoclonal antibodies.
Kuhns S, Shu J, Xiang C, Guzman R, Zhang Q, Bretzlaff W, Miscalichi N, Kalenian K, Joubert M.
Kuhns S, et al. Among authors: bretzlaff w.
J Biotechnol. 2020 Jun 20;317:5-15. doi: 10.1016/j.jbiotec.2020.04.017. Epub 2020 May 1.
J Biotechnol. 2020.
PMID: 32361021
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