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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, Saeed F, Wostein H, Walko T 3rd, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, Yurko R, Finn P, Look G, Rishton G, Safferstein H, Miller M, Johanson C, Stopa E, Windisch M, Hutter-Paier B, Shamloo M, Arancio O, LeVine H 3rd, Catalano SM. Izzo NJ, et al. Among authors: look g. PLoS One. 2014 Nov 12;9(11):e111898. doi: 10.1371/journal.pone.0111898. eCollection 2014. PLoS One. 2014. PMID: 25390368 Free PMC article.
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity.
Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H 3rd, Spires-Jones TL, Catalano SM. Izzo NJ, et al. Among authors: look g. PLoS One. 2014 Nov 12;9(11):e111899. doi: 10.1371/journal.pone.0111899. eCollection 2014. PLoS One. 2014. PMID: 25390692 Free PMC article.
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.
Izzo NJ, Yuede CM, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Waybright L, Look G, Rishton G, Safferstein H, Hamby ME, Williams C, Sadlek K, Edwards HM, Davis CS, Grundman M, Schneider LS, DeKosky ST, Chelsky D, Pike I, Henstridge C, Blennow K, Zetterberg H, LeVine H 3rd, Spires-Jones TL, Cirrito JR, Catalano SM. Izzo NJ, et al. Among authors: look g. Alzheimers Dement. 2021 Aug;17(8):1365-1382. doi: 10.1002/alz.12302. Epub 2021 Feb 8. Alzheimers Dement. 2021. PMID: 33559354 Free PMC article. Clinical Trial.
Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease.
Look GC, Jerecic J, Cherbavaz DB, Pray TR, Breach JC, Crosier WJ, Igoudin L, Hironaka CM, Lowe RM, McEntee M, Ruslim-Litrus L, Wu HM, Zhang S, Catalano SM, Goure WF, Summa D, Krafft GA. Look GC, et al. Curr Alzheimer Res. 2007 Dec;4(5):562-7. doi: 10.2174/156720507783018271. Curr Alzheimer Res. 2007. PMID: 18220523 Review.
Screening for novel antimicrobials from encoded combinatorial libraries by using a two-dimensional agar format.
Silen JL, Lu AT, Solas DW, Gore MA, MacLean D, Shah NH, Coffin JM, Bhinderwala NS, Wang Y, Tsutsui KT, Look GC, Campbell DA, Hale RL, Navre M, DeLuca-Flaherty CR. Silen JL, et al. Among authors: look gc. Antimicrob Agents Chemother. 1998 Jun;42(6):1447-53. doi: 10.1128/AAC.42.6.1447. Antimicrob Agents Chemother. 1998. PMID: 9624492 Free PMC article.
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