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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, Saeed F, Wostein H, Walko T 3rd, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, Yurko R, Finn P, Look G, Rishton G, Safferstein H, Miller M, Johanson C, Stopa E, Windisch M, Hutter-Paier B, Shamloo M, Arancio O, LeVine H 3rd, Catalano SM. Izzo NJ, et al. Among authors: saeed f. PLoS One. 2014 Nov 12;9(11):e111898. doi: 10.1371/journal.pone.0111898. eCollection 2014. PLoS One. 2014. PMID: 25390368 Free PMC article.
Dynamin 1 is required for memory formation.
Fà M, Staniszewski A, Saeed F, Francis YI, Arancio O. Fà M, et al. Among authors: saeed f. PLoS One. 2014 Mar 18;9(3):e91954. doi: 10.1371/journal.pone.0091954. eCollection 2014. PLoS One. 2014. PMID: 24643165 Free PMC article.
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.
Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Fà M, et al. Among authors: saeed f. J Alzheimers Dis. 2016;49(3):707-21. doi: 10.3233/JAD-150618. J Alzheimers Dis. 2016. PMID: 26484927 Free PMC article.
Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM. Roy SM, et al. Among authors: saeed f. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. doi: 10.1021/acschemneuro.5b00002. Epub 2015 Feb 23. ACS Chem Neurosci. 2015. PMID: 25676389 Free PMC article.
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.
Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D'Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O. Fá M, et al. Among authors: saeed f. Sci Rep. 2016 Jan 20;6:19393. doi: 10.1038/srep19393. Sci Rep. 2016. PMID: 26786552 Free PMC article.
526 results