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Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT. Mansour MR, et al. Among authors: durbin ad. Science. 2014 Dec 12;346(6215):1373-7. doi: 10.1126/science.1259037. Epub 2014 Nov 13. Science. 2014. PMID: 25394790 Free PMC article.
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, Wei JS, Khan J, Bramlett K, Rahman N, Capasso M, Iolascon A, Gerhard DS, Guidry Auvil JM, Young RA, Hakonarson H, Diskin SJ, Look AT, Maris JM. Oldridge DA, et al. Among authors: durbin ad. Nature. 2015 Dec 17;528(7582):418-21. doi: 10.1038/nature15540. Epub 2015 Nov 11. Nature. 2015. PMID: 26560027 Free PMC article.
Malignant Peripheral Nerve Sheath Tumors.
Durbin AD, Ki DH, He S, Look AT. Durbin AD, et al. Adv Exp Med Biol. 2016;916:495-530. doi: 10.1007/978-3-319-30654-4_22. Adv Exp Med Biol. 2016. PMID: 27165368 Review.
MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.
Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look AT. Zimmerman MW, et al. Among authors: durbin ad. Cancer Discov. 2018 Mar;8(3):320-335. doi: 10.1158/2159-8290.CD-17-0993. Epub 2017 Dec 28. Cancer Discov. 2018. PMID: 29284669 Free PMC article.
Retracted: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT. Morita K, et al. Among authors: durbin ad. Cell. 2020 Apr 30;181(3):702-715.e20. doi: 10.1016/j.cell.2020.03.051. Epub 2020 Apr 20. Cell. 2020. Retraction in: Cell. 2022 Aug 4;185(16):3058. doi: 10.1016/j.cell.2022.07.008 PMID: 32315619 Free PMC article. Retracted.
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Tao T, Shi H, Mariani L, Abraham BJ, Durbin AD, Zimmerman MW, Powers JT, Missios P, Ross KN, Perez-Atayde AR, Bulyk ML, Young RA, Daley GQ, Look AT. Tao T, et al. Among authors: durbin ad. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16516-16526. doi: 10.1073/pnas.1922692117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601179 Free PMC article.
49 results