Wightman F - Search Results

1

Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy.

Lu HK, Gray LR, Wightman F, Ellenberg P, Khoury G, Cheng WJ, Mota TM, Wesselingh S, Gorry PR, Cameron PU, Churchill MJ, Lewin SR. Lu HK, et al. Among authors: wightman f. PLoS One. 2014 Nov 19;9(11):e113341. doi: 10.1371/journal.pone.0113341. eCollection 2014. PLoS One. 2014. PMID: 25409334 Free PMC article.

2

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.

Shehu-Xhilaga M, Rhodes D, Wightman F, Liu HB, Solomon A, Saleh S, Dear AE, Cameron PU, Lewin SR. Shehu-Xhilaga M, et al. Among authors: wightman f. AIDS. 2009 Sep 24;23(15):2047-50. doi: 10.1097/QAD.0b013e328330342c. AIDS. 2009. PMID: 19609198

3

Both CD31(+) and CD31⁻ naive CD4(+) T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapy.

Wightman F, Solomon A, Khoury G, Green JA, Gray L, Gorry PR, Ho YS, Saksena NK, Hoy J, Crowe SM, Cameron PU, Lewin SR. Wightman F, et al. J Infect Dis. 2010 Dec 1;202(11):1738-48. doi: 10.1086/656721. Epub 2010 Oct 27. J Infect Dis. 2010. PMID: 20979453

4

HDAC inhibitors in HIV.

Wightman F, Ellenberg P, Churchill M, Lewin SR. Wightman F, et al. Immunol Cell Biol. 2012 Jan;90(1):47-54. doi: 10.1038/icb.2011.95. Epub 2011 Nov 15. Immunol Cell Biol. 2012. PMID: 22083528 Review.

5

HIV reservoirs and strategies for eradication.

Smith MZ, Wightman F, Lewin SR. Smith MZ, et al. Among authors: wightman f. Curr HIV/AIDS Rep. 2012 Mar;9(1):5-15. doi: 10.1007/s11904-011-0108-2. Curr HIV/AIDS Rep. 2012. PMID: 22249405 Review.

6

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells.

Wightman F, Lu HK, Solomon AE, Saleh S, Harman AN, Cunningham AL, Gray L, Churchill M, Cameron PU, Dear AE, Lewin SR. Wightman F, et al. AIDS. 2013 Nov 28;27(18):2853-62. doi: 10.1097/QAD.0000000000000067. AIDS. 2013. PMID: 24189584 Free PMC article.

7

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

Elliott JH, Wightman F, Solomon A, Ghneim K, Ahlers J, Cameron MJ, Smith MZ, Spelman T, McMahon J, Velayudham P, Brown G, Roney J, Watson J, Prince MH, Hoy JF, Chomont N, Fromentin R, Procopio FA, Zeidan J, Palmer S, Odevall L, Johnstone RW, Martin BP, Sinclair E, Deeks SG, Hazuda DJ, Cameron PU, Sékaly RP, Lewin SR. Elliott JH, et al. Among authors: wightman f. PLoS Pathog. 2014 Nov 13;10(10):e1004473. doi: 10.1371/journal.ppat.1004473. eCollection 2014 Oct. PLoS Pathog. 2014. PMID: 25393648 Free PMC article. Clinical Trial.

8

No adverse safety or virological changes 2 years following vorinostat in HIV-infected individuals on antiretroviral therapy.

Mota TM, Rasmussen TA, Rhodes A, Tennakoon S, Dantanarayana A, Wightman F, Hagenauer M, Roney J, Spelman T, Purcell DFJ, McMahon J, Hoy JF, Prince HM, Elliott JH, Lewin SR. Mota TM, et al. Among authors: wightman f. AIDS. 2017 May 15;31(8):1137-1141. doi: 10.1097/QAD.0000000000001442. AIDS. 2017. PMID: 28301423 Free PMC article.

9

Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy.

Chang JJ, Wightman F, Bartholomeusz A, Ayres A, Kent SJ, Sasadeusz J, Lewin SR. Chang JJ, et al. Among authors: wightman f. J Virol. 2005 Mar;79(5):3038-51. doi: 10.1128/JVI.79.5.3038-3051.2005. J Virol. 2005. PMID: 15709024 Free PMC article.

10

Enhanced replicative capacity and pathogenicity of HIV-1 isolated from individuals infected with drug-resistant virus and declining CD4+ T-cell counts.

Solomon A, Lane N, Wightman F, Gorry PR, Lewin SR. Solomon A, et al. Among authors: wightman f. J Acquir Immune Defic Syndr. 2005 Oct 1;40(2):140-8. doi: 10.1097/01.qai.0000173460.75322.93. J Acquir Immune Defic Syndr. 2005. PMID: 16186730

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