Paoletta S - Search Results

1

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.

Tosh DK, Finley A, Paoletta S, Moss SM, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. Tosh DK, et al. Among authors: paoletta s. J Med Chem. 2014 Dec 11;57(23):9901-14. doi: 10.1021/jm501021n. Epub 2014 Nov 25. J Med Chem. 2014. PMID: 25422861 Free PMC article.

2

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Tosh DK, Paoletta S, Deflorian F, Phan K, Moss SM, Gao ZG, Jiang X, Jacobson KA. Tosh DK, et al. Among authors: paoletta s. J Med Chem. 2012 Sep 27;55(18):8075-90. doi: 10.1021/jm300965a. Epub 2012 Sep 10. J Med Chem. 2012. PMID: 22921089 Free PMC article.

3

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.

Tosh DK, Paoletta S, Phan K, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: paoletta s. ACS Med Chem Lett. 2012 Jul 12;3(7):596-601. doi: 10.1021/ml300107e. Epub 2012 Jun 11. ACS Med Chem Lett. 2012. PMID: 23145215 Free PMC article.

4

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.

Paoletta S, Tosh DK, Finley A, Gizewski ET, Moss SM, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA. Paoletta S, et al. J Med Chem. 2013 Jul 25;56(14):5949-63. doi: 10.1021/jm4007966. Epub 2013 Jul 3. J Med Chem. 2013. PMID: 23789857 Free PMC article.

5

Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners.

Paoletta S, Tosh DK, Salvemini D, Jacobson KA. Paoletta S, et al. PLoS One. 2014 May 23;9(5):e97858. doi: 10.1371/journal.pone.0097858. eCollection 2014. PLoS One. 2014. PMID: 24859150 Free PMC article.

6

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators.

Toti KS, Moss SM, Paoletta S, Gao ZG, Jacobson KA, Van Calenbergh S. Toti KS, et al. Among authors: paoletta s. Bioorg Med Chem. 2014 Aug 1;22(15):4257-68. doi: 10.1016/j.bmc.2014.05.036. Epub 2014 May 23. Bioorg Med Chem. 2014. PMID: 24931275 Free PMC article.

7

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

Tosh DK, Paoletta S, Chen Z, Moss SM, Gao ZG, Salvemini D, Jacobson KA. Tosh DK, et al. Among authors: paoletta s. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3302-6. doi: 10.1016/j.bmcl.2014.06.006. Epub 2014 Jun 11. Bioorg Med Chem Lett. 2014. PMID: 24969016 Free PMC article.

8

Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.

Moss SM, Jayasekara PS, Paoletta S, Gao ZG, Jacobson KA. Moss SM, et al. Among authors: paoletta s. ACS Med Chem Lett. 2014 Jul 11;5(9):1043-8. doi: 10.1021/ml5002486. eCollection 2014 Sep 11. ACS Med Chem Lett. 2014. PMID: 25221664 Free PMC article.

9

Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.

Trujillo K, Paoletta S, Kiselev E, Jacobson KA. Trujillo K, et al. Among authors: paoletta s. Bioorg Med Chem. 2015 Jul 15;23(14):4056-64. doi: 10.1016/j.bmc.2015.03.042. Epub 2015 Mar 21. Bioorg Med Chem. 2015. PMID: 25868749 Free PMC article.

10

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.

Tosh DK, Crane S, Chen Z, Paoletta S, Gao ZG, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA. Tosh DK, et al. Among authors: paoletta s. ACS Med Chem Lett. 2015 May 20;6(7):804-8. doi: 10.1021/acsmedchemlett.5b00150. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191370 Free PMC article.

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