Tosh DK - Search Results

1

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.

Tosh DK, Finley A, Paoletta S, Moss SM, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA. Tosh DK, et al. J Med Chem. 2014 Dec 11;57(23):9901-14. doi: 10.1021/jm501021n. Epub 2014 Nov 25. J Med Chem. 2014. PMID: 25422861 Free PMC article.

2

Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.

Jeong LS, Choe SA, Gunaga P, Kim HO, Lee HW, Lee SK, Tosh DK, Patel A, Palaniappan KK, Gao ZG, Jacobson KA, Moon HR. Jeong LS, et al. Among authors: tosh dk. J Med Chem. 2007 Jul 12;50(14):3159-62. doi: 10.1021/jm070259t. Epub 2007 Jun 8. J Med Chem. 2007. PMID: 17555308

3

Stereoselective synthesis of 1'-functionalized-4'-thionucleosides.

Jeong LS, Gunaga P, Kim HO, Tosh DK, Lee HW, Choe SA, Moon HR, Gao ZG, Jacobson KA, Chun MW. Jeong LS, et al. Among authors: tosh dk. Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1011-4. doi: 10.1080/15257770701508588. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18058527 Free PMC article.

4

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.

Jeong LS, Lee HW, Kim HO, Tosh DK, Pal S, Choi WJ, Gao ZG, Patel AR, Williams W, Jacobson KA, Kim HD. Jeong LS, et al. Among authors: tosh dk. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1612-6. doi: 10.1016/j.bmcl.2008.01.070. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18255292 Free PMC article.

5

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.

Jeong LS, Pal S, Choe SA, Choi WJ, Jacobson KA, Gao ZG, Klutz AM, Hou X, Kim HO, Lee HW, Lee SK, Tosh DK, Moon HR. Jeong LS, et al. Among authors: tosh dk. J Med Chem. 2008 Oct 23;51(20):6609-13. doi: 10.1021/jm8008647. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811138 Free PMC article.

6

Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.

Tosh DK, Chinn M, Ivanov AA, Klutz AM, Gao ZG, Jacobson KA. Tosh DK, et al. J Med Chem. 2009 Dec 10;52(23):7580-92. doi: 10.1021/jm900426g. J Med Chem. 2009. PMID: 19499950 Free PMC article.

7

Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.

Jacobson KA, Klutz AM, Tosh DK, Ivanov AA, Preti D, Baraldi PG. Jacobson KA, et al. Among authors: tosh dk. Handb Exp Pharmacol. 2009;(193):123-59. doi: 10.1007/978-3-540-89615-9_5. Handb Exp Pharmacol. 2009. PMID: 19639281 Free PMC article. Review.

8

2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.

Tosh DK, Chinn M, Yoo LS, Kang DW, Luecke H, Gao ZG, Jacobson KA. Tosh DK, et al. Bioorg Med Chem. 2010 Jan 15;18(2):508-17. doi: 10.1016/j.bmc.2009.12.018. Epub 2009 Dec 11. Bioorg Med Chem. 2010. PMID: 20036562 Free PMC article.

9

Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.

Tosh DK, Yoo LS, Chinn M, Hong K, Kilbey SM 2nd, Barrett MO, Fricks IP, Harden TK, Gao ZG, Jacobson KA. Tosh DK, et al. Bioconjug Chem. 2010 Feb 17;21(2):372-84. doi: 10.1021/bc900473v. Bioconjug Chem. 2010. PMID: 20121074 Free PMC article.

10

Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.

Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA. Maruoka H, et al. Among authors: tosh dk. J Med Chem. 2010 Jun 10;53(11):4488-501. doi: 10.1021/jm100287t. J Med Chem. 2010. PMID: 20446735 Free PMC article.

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