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Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong JY, Tan YK, Thumboo J, van Loosdregt J, Albani S. Rossetti M, et al. J Immunol. 2015 Jan 1;194(1):113-24. doi: 10.4049/jimmunol.1401145. Epub 2014 Dec 1. J Immunol. 2015. PMID: 25452562 Free PMC article.
A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples.
Spreafico R, Rossetti M, van den Broek T, Jansen NJ, Zhang H, Moshref M, Prakken B, van Loosdregt J, van Wijk F, Albani S. Spreafico R, et al. Among authors: rossetti m. Eur J Immunol. 2014 Oct;44(10):3141-3. doi: 10.1002/eji.201444627. Epub 2014 Aug 25. Eur J Immunol. 2014. PMID: 25042685 Free article. No abstract available.
TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis.
Rossetti M, Spreafico R, Consolaro A, Leong JY, Chua C, Massa M, Saidin S, Magni-Manzoni S, Arkachaisri T, Wallace CA, Gattorno M, Martini A, Lovell DJ, Albani S. Rossetti M, et al. Ann Rheum Dis. 2017 Feb;76(2):435-441. doi: 10.1136/annrheumdis-2015-208992. Epub 2016 Jun 16. Ann Rheum Dis. 2017. PMID: 27311837 Free PMC article.
A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment.
Spreafico R, Rossetti M, van Loosdregt J, Wallace CA, Massa M, Magni-Manzoni S, Gattorno M, Martini A, Lovell DJ, Albani S. Spreafico R, et al. Among authors: rossetti m. Ann Rheum Dis. 2016 Feb;75(2):459-65. doi: 10.1136/annrheumdis-2014-206226. Epub 2014 Dec 12. Ann Rheum Dis. 2016. PMID: 25498120 Free PMC article.
Human neonatal thymectomy induces altered B-cell responses and autoreactivity.
van den Broek T, Madi A, Delemarre EM, Schadenberg AWL, Tesselaar K, Borghans JAM, Nierkens S, Redegeld FA, Otten HG, Rossetti M, Albani S, Sorek R, Cohen IR, Jansen NJG, van Wijk F. van den Broek T, et al. Among authors: rossetti m. Eur J Immunol. 2017 Nov;47(11):1970-1981. doi: 10.1002/eji.201746971. Epub 2017 Sep 6. Eur J Immunol. 2017. PMID: 28691750 Free PMC article.
650 results