Francis K - Search Results

1

Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100.

Liu CT, Francis K, Layfield JP, Huang X, Hammes-Schiffer S, Kohen A, Benkovic SJ. Liu CT, et al. Among authors: francis k. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18231-6. doi: 10.1073/pnas.1415940111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453098 Free PMC article.

2

Preservation of protein dynamics in dihydrofolate reductase evolution.

Francis K, Stojkovic V, Kohen A. Francis K, et al. J Biol Chem. 2013 Dec 13;288(50):35961-8. doi: 10.1074/jbc.M113.507632. Epub 2013 Oct 24. J Biol Chem. 2013. PMID: 24158440 Free PMC article.

3

Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.

Singh P, Sen A, Francis K, Kohen A. Singh P, et al. Among authors: francis k. J Am Chem Soc. 2014 Feb 12;136(6):2575-82. doi: 10.1021/ja411998h. Epub 2014 Jan 31. J Am Chem Soc. 2014. PMID: 24450297 Free PMC article.

4

Protein motions and the activation of the CH bond catalyzed by dihydrofolate reductase.

Francis K, Kohen A. Francis K, et al. Curr Opin Chem Biol. 2014 Aug;21:19-24. doi: 10.1016/j.cbpa.2014.03.009. Epub 2014 Apr 16. Curr Opin Chem Biol. 2014. PMID: 24742825 Free PMC article. Review.

5

Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase.

Li J, Lin J, Kohen A, Singh P, Francis K, Cheatum CM. Li J, et al. Among authors: francis k. Biochemistry. 2021 Dec 21;60(50):3822-3828. doi: 10.1021/acs.biochem.1c00558. Epub 2021 Dec 7. Biochemistry. 2021. PMID: 34875176 Free PMC article.

6

The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase.

Francis K, Sapienza PJ, Lee AL, Kohen A. Francis K, et al. Biochemistry. 2016 Feb 23;55(7):1100-6. doi: 10.1021/acs.biochem.5b00945. Epub 2016 Feb 9. Biochemistry. 2016. PMID: 26813442 Free PMC article.

7

Network of remote and local protein dynamics in dihydrofolate reductase catalysis.

Singh P, Francis K, Kohen A. Singh P, et al. Among authors: francis k. ACS Catal. 2015 May 1;5(5):3067-3073. doi: 10.1021/acscatal.5b00331. Epub 2015 Apr 8. ACS Catal. 2015. PMID: 27182453 Free PMC article.

8

Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.

Guo Q, Gakhar L, Wickersham K, Francis K, Vardi-Kilshtain A, Major DT, Cheatum CM, Kohen A. Guo Q, et al. Among authors: francis k. Biochemistry. 2016 May 17;55(19):2760-71. doi: 10.1021/acs.biochem.6b00181. Epub 2016 May 3. Biochemistry. 2016. PMID: 27100912 Free PMC article.

9

The biochemistry of the metabolic poison propionate 3-nitronate and its conjugate acid, 3-nitropropionate.

Francis K, Smitherman C, Nishino SF, Spain JC, Gadda G. Francis K, et al. IUBMB Life. 2013 Sep;65(9):759-68. doi: 10.1002/iub.1195. Epub 2013 Jul 29. IUBMB Life. 2013. PMID: 23893873 Free article. Review.

10

Inflated kinetic isotope effects in the branched mechanism of Neurospora crassa 2-nitropropane dioxygenase.

Francis K, Gadda G. Francis K, et al. Biochemistry. 2009 Mar 24;48(11):2403-10. doi: 10.1021/bi802238j. Biochemistry. 2009. PMID: 19199786

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