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Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: norris j. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22. Bioorg Med Chem. 2014. PMID: 25456083 Free PMC article.
Synthesis and bioevaluation of omega-N-amino analogs of B13.
Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: norris j. Bioorg Med Chem. 2009 Mar 1;17(5):1840-8. doi: 10.1016/j.bmc.2009.01.057. Epub 2009 Jan 31. Bioorg Med Chem. 2009. PMID: 19217788 Free PMC article.
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential anticancer agents deprived of unwanted lysosomal destabilization and ACDase proteolytic degradation properties of LCL204 [Szulc, Z. M.; Mayro …
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential a …
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS. Holman DH, et al. Among authors: norris k, norris js. Cancer Chemother Pharmacol. 2008 Feb;61(2):231-42. doi: 10.1007/s00280-007-0465-0. Epub 2007 Apr 12. Cancer Chemother Pharmacol. 2008. PMID: 17429631
Acid ceramidase inhibition: a novel target for cancer therapy.
Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, Bielawski J, Dong JY, El-Zawahry AM, Guo GW, Hannun YA, Holman DH, Rubinchik S, Szulc Z, Keane TE, Tavassoli M, Norris JS. Liu X, et al. Among authors: norris js. Front Biosci. 2008 Jan 1;13:2293-8. doi: 10.2741/2843. Front Biosci. 2008. PMID: 17981711 Review.
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X. Mahdy AE, et al. Among authors: norris js. Mol Ther. 2009 Mar;17(3):430-8. doi: 10.1038/mt.2008.281. Epub 2008 Dec 23. Mol Ther. 2009. PMID: 19107118 Free PMC article.
2,101 results