Leyh TS - Search Results

1

Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability.

Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB. Kang S, et al. Among authors: leyh ts. Eur J Med Chem. 2015 Jan 27;90:448-61. doi: 10.1016/j.ejmech.2014.11.040. Epub 2014 Nov 22. Eur J Med Chem. 2015. PMID: 25461893 Free PMC article.

2

Defining the mandate of proteomics in the post-genomics era: workshop report.

Kenyon GL, DeMarini DM, Fuchs E, Galas DJ, Kirsch JF, Leyh TS, Moos WH, Petsko GA, Ringe D, Rubin GM, Sheahan LC; National Research Council Steering Committee. Kenyon GL, et al. Among authors: leyh ts. Mol Cell Proteomics. 2002 Oct;1(10):763-80. Mol Cell Proteomics. 2002. PMID: 12438560 Free article.

3

Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae.

Kudoh T, Park CS, Lefurgy ST, Sun M, Michels T, Leyh TS, Silverman RB. Kudoh T, et al. Among authors: leyh ts. Bioorg Med Chem. 2010 Feb;18(3):1124-34. doi: 10.1016/j.bmc.2009.12.050. Epub 2009 Dec 24. Bioorg Med Chem. 2010. PMID: 20056424 Free PMC article.

4

Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae.

Lefurgy ST, Rodriguez SB, Park CS, Cahill S, Silverman RB, Leyh TS. Lefurgy ST, et al. Among authors: leyh ts. J Biol Chem. 2010 Jul 2;285(27):20654-63. doi: 10.1074/jbc.M109.098350. Epub 2010 Apr 19. J Biol Chem. 2010. PMID: 20404339 Free PMC article.

5

Backbone 1H, 13C, 15N NMR assignments of the unliganded and substrate ternary complex forms of mevalonate diphosphate decarboxylase from Streptococcus pneumoniae.

Reuther G, Harris R, Girvin M, Leyh TS. Reuther G, et al. Among authors: leyh ts. Biomol NMR Assign. 2011 Apr;5(1):11-4. doi: 10.1007/s12104-010-9255-4. Epub 2010 Aug 25. Biomol NMR Assign. 2011. PMID: 20737255 Free PMC article.

6

An enzymatic platform for the synthesis of isoprenoid precursors.

Rodriguez SB, Leyh TS. Rodriguez SB, et al. Among authors: leyh ts. PLoS One. 2014 Aug 25;9(8):e105594. doi: 10.1371/journal.pone.0105594. eCollection 2014. PLoS One. 2014. PMID: 25153179 Free PMC article.

7

The kinetic mechanism of phosphomevalonate kinase.

Pilloff D, Dabovic K, Romanowski MJ, Bonanno JB, Doherty M, Burley SK, Leyh TS. Pilloff D, et al. Among authors: leyh ts. J Biol Chem. 2003 Feb 14;278(7):4510-5. doi: 10.1074/jbc.M210551200. Epub 2002 Nov 6. J Biol Chem. 2003. PMID: 12424232 Free article.

8

The NSAID allosteric site of human cytosolic sulfotransferases.

Wang T, Cook I, Leyh TS. Wang T, et al. Among authors: leyh ts. J Biol Chem. 2017 Dec 8;292(49):20305-20312. doi: 10.1074/jbc.M117.817387. Epub 2017 Oct 16. J Biol Chem. 2017. PMID: 29038294 Free PMC article.

9

Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target.

Andreassi JL 2nd, Dabovic K, Leyh TS. Andreassi JL 2nd, et al. Among authors: leyh ts. Biochemistry. 2004 Dec 28;43(51):16461-6. doi: 10.1021/bi048075t. Biochemistry. 2004. PMID: 15610040

10

The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis.

Sun M, Andreassi JL 2nd, Liu S, Pinto R, Triccas JA, Leyh TS. Sun M, et al. Among authors: leyh ts. J Biol Chem. 2005 Mar 4;280(9):7861-6. doi: 10.1074/jbc.M409613200. Epub 2004 Dec 22. J Biol Chem. 2005. PMID: 15615729 Free article.

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