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Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.
Tan L, Perez J, Mela M, Miranda E, Burling KA, Rouhani FN, DeMeo DL, Haq I, Irving JA, Ordóñez A, Dickens JA, Brantly M, Marciniak SJ, Alexander GJ, Gooptu B, Lomas DA. Tan L, et al. Among authors: perez j. Int J Biochem Cell Biol. 2015 Jan;58:81-91. doi: 10.1016/j.biocel.2014.11.005. Epub 2014 Nov 13. Int J Biochem Cell Biol. 2015. PMID: 25462157 Free PMC article.
Circulating polymers in α1-antitrypsin deficiency.
Tan L, Dickens JA, Demeo DL, Miranda E, Perez J, Rashid ST, Day J, Ordoñez A, Marciniak SJ, Haq I, Barker AF, Campbell EJ, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Rouhani FN, Brantly M, Lomas DA. Tan L, et al. Among authors: perez j. Eur Respir J. 2014 May;43(5):1501-4. doi: 10.1183/09031936.00111213. Epub 2014 Mar 6. Eur Respir J. 2014. PMID: 24603821 Free article. No abstract available.
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Motamedi-Shad N, Jagger AM, Liedtke M, Faull SV, Nanda AS, Salvadori E, Wort JL, Kay CW, Heyer-Chauhan N, Miranda E, Perez J, Ordóñez A, Haq I, Irving JA, Lomas DA. Motamedi-Shad N, et al. Among authors: perez j. Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12. Biochem J. 2016. PMID: 27407165 Free PMC article.
Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
Laffranchi M, Elliston EL, Miranda E, Perez J, Ronzoni R, Jagger AM, Heyer-Chauhan N, Brantly ML, Fra A, Lomas DA, Irving JA. Laffranchi M, et al. Among authors: perez j. JCI Insight. 2020 Jul 23;5(14):e135459. doi: 10.1172/jci.insight.135459. JCI Insight. 2020. PMID: 32699193 Free PMC article.
The serpinopathies studying serpin polymerization in vivo.
Irving JA, Ekeowa UI, Belorgey D, Haq I, Gooptu B, Miranda E, Pérez J, Roussel BD, Ordóñez A, Dalton LE, Thomas SE, Marciniak SJ, Parfrey H, Chilvers ER, Teckman JH, Alam S, Mahadeva R, Rashid ST, Vallier L, Lomas DA. Irving JA, et al. Among authors: perez j. Methods Enzymol. 2011;501:421-66. doi: 10.1016/B978-0-12-385950-1.00018-3. Methods Enzymol. 2011. PMID: 22078544
Polymers of Z α1-antitrypsin are secreted in cell models of disease.
Fra A, Cosmi F, Ordoñez A, Berardelli R, Perez J, Guadagno NA, Corda L, Marciniak SJ, Lomas DA, Miranda E. Fra A, et al. Among authors: perez j. Eur Respir J. 2016 Mar;47(3):1005-9. doi: 10.1183/13993003.00940-2015. Epub 2016 Feb 4. Eur Respir J. 2016. PMID: 26846838 Free article. No abstract available.
5,289 results