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Page 1
Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis.
Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo'oka T. Inoue K, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:24-34. doi: 10.1016/j.jchromb.2014.10.022. Epub 2014 Oct 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25463194
Towards the chiral metabolomics: Liquid chromatography-mass spectrometry based DL-amino acid analysis after labeling with a new chiral reagent, (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate, and the application to saliva of healthy volunteers.
Mochizuki T, Takayama T, Todoroki K, Inoue K, Min JZ, Toyo'oka T. Mochizuki T, et al. Anal Chim Acta. 2015 May 22;875:73-82. doi: 10.1016/j.aca.2015.02.054. Epub 2015 Feb 23. Anal Chim Acta. 2015. PMID: 25937108
Novel chiral derivatization reagents possessing a pyridylthiourea structure for enantiospecific determination of amines and carboxylic acids in high-throughput liquid chromatography and electrospray-ionization mass spectrometry for chiral metabolomics identification.
Nagao R, Tsutsui H, Mochizuki T, Takayama T, Kuwabara T, Min JZ, Inoue K, Todoroki K, Toyo'oka T. Nagao R, et al. J Chromatogr A. 2013 Jun 28;1296:111-8. doi: 10.1016/j.chroma.2013.03.019. Epub 2013 Mar 26. J Chromatogr A. 2013. PMID: 23582770
Metabolic profiling of Alzheimer's disease brains.
Inoue K, Tsutsui H, Akatsu H, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T. Inoue K, et al. Sci Rep. 2013;3:2364. doi: 10.1038/srep02364. Sci Rep. 2013. PMID: 23917584 Free PMC article.
Simultaneous determination of post-translational racemization and isomerization of N-terminal amyloid-β in Alzheimer's brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry.
Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Yamamoto T, Toyo'oka T. Inoue K, et al. Anal Chem. 2014 Jan 7;86(1):797-804. doi: 10.1021/ac403315h. Epub 2013 Dec 9. Anal Chem. 2014. PMID: 24283798
Profiling of chiral and achiral carboxylic acid metabolomics: synthesis and evaluation of triazine-type chiral derivatization reagents for carboxylic acids by LC-ESI-MS/MS and the application to saliva of healthy volunteers and diabetic patients.
Takayama T, Kuwabara T, Maeda T, Noge I, Kitagawa Y, Inoue K, Todoroki K, Min JZ, Toyo'oka T. Takayama T, et al. Anal Bioanal Chem. 2015 Jan;407(3):1003-14. doi: 10.1007/s00216-014-8275-9. Epub 2014 Nov 1. Anal Bioanal Chem. 2015. PMID: 25366977
358 results