Lopus M - Search Results

1

Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents.

Santoshi S, Manchukonda NK, Suri C, Sharma M, Sridhar B, Joseph S, Lopus M, Kantevari S, Baitharu I, Naik PK. Santoshi S, et al. Among authors: lopus m. J Comput Aided Mol Des. 2015 Mar;29(3):249-70. doi: 10.1007/s10822-014-9820-5. Epub 2014 Dec 7. J Comput Aided Mol Des. 2015. PMID: 25481458

2

In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

Naik PK, Lopus M, Aneja R, Vangapandu SN, Joshi HC. Naik PK, et al. Among authors: lopus m. J Comput Aided Mol Des. 2012 Feb;26(2):233-47. doi: 10.1007/s10822-011-9508-z. Epub 2011 Dec 15. J Comput Aided Mol Des. 2012. PMID: 22170255

3

Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents.

Manchukonda NK, Naik PK, Santoshi S, Lopus M, Joseph S, Sridhar B, Kantevari S. Manchukonda NK, et al. Among authors: lopus m. PLoS One. 2013 Oct 21;8(10):e77970. doi: 10.1371/journal.pone.0077970. eCollection 2013. PLoS One. 2013. PMID: 24205049 Free PMC article.

4

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics.

Lopus M, Naik PK. Lopus M, et al. Pharmacol Rep. 2015 Feb;67(1):56-62. doi: 10.1016/j.pharep.2014.09.003. Epub 2014 Sep 20. Pharmacol Rep. 2015. PMID: 25560576 Review.

5

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents.

Mishra RC, Gundala SR, Karna P, Lopus M, Gupta KK, Nagaraju M, Hamelberg D, Tandon V, Panda D, Reid MD, Aneja R. Mishra RC, et al. Among authors: lopus m. Bioorg Med Chem Lett. 2015;25(10):2133-40. doi: 10.1016/j.bmcl.2015.03.076. Epub 2015 Mar 31. Bioorg Med Chem Lett. 2015. PMID: 25891106 Free PMC article.

6

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.

Mahaddalkar T, Suri C, Naik PK, Lopus M. Mahaddalkar T, et al. Among authors: lopus m. Eur J Pharmacol. 2015 Aug 5;760:154-62. doi: 10.1016/j.ejphar.2015.04.014. Epub 2015 Apr 23. Eur J Pharmacol. 2015. PMID: 25912799

7

Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.

Mahaddalkar T, Naik PK, Choudhary S, Manchukonda N, Kantevari S, Lopus M. Mahaddalkar T, et al. Among authors: lopus m. J Biomol Struct Dyn. 2017 Aug;35(11):2475-2484. doi: 10.1080/07391102.2016.1222969. Epub 2016 Aug 31. J Biomol Struct Dyn. 2017. PMID: 27576773 No abstract available.

8

Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells.

Cheriyamundath S, Mahaddalkar T, Kantevari S, Lopus M. Cheriyamundath S, et al. Among authors: lopus m. Biomed Pharmacother. 2017 Feb;86:74-80. doi: 10.1016/j.biopha.2016.11.143. Epub 2016 Dec 7. Biomed Pharmacother. 2017. PMID: 27939522

9

Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol.

Pradhan M, Suri C, Choudhary S, Naik PK, Lopus M. Pradhan M, et al. Among authors: lopus m. J Biomol Struct Dyn. 2018 Jan;36(1):195-208. doi: 10.1080/07391102.2016.1271749. Epub 2016 Dec 29. J Biomol Struct Dyn. 2018. PMID: 27960611

10

Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine.

Pradhan S, Mahaddalkar T, Choudhary S, Manhcukonda N, Nagireddy PR, Kantevari S, Lopus M. Pradhan S, et al. Among authors: lopus m. Curr Top Med Chem. 2017;17(22):2569-2574. doi: 10.2174/1568026617666170104150304. Curr Top Med Chem. 2017. PMID: 28056737 Review.

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