McFarlane CS - Search Results

1

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Denis D, Foster A, Fortin R, Leger S, McFarlane CS, Morton H, et al. Gillard J, et al. Among authors: mcfarlane cs. Can J Physiol Pharmacol. 1989 May;67(5):456-64. doi: 10.1139/y89-073. Can J Physiol Pharmacol. 1989. PMID: 2548691

2

Effects of a 5-lipoxygenase inhibitor (L-651,392) on primary and late pulmonary responses to ascaris antigen in the squirrel monkey.

McFarlane CS, Hamel R, Ford-Hutchinson AW. McFarlane CS, et al. Agents Actions. 1987 Oct;22(1-2):63-8. doi: 10.1007/BF01968818. Agents Actions. 1987. PMID: 3687598

3

Effects of a 5-lipoxygenase inhibitor (L-651,392) and leukotriene D4 antagonist (L-649,923) in two animal models of immediate hypersensitivity reactions.

Letts LG, McFarlane C, Piechuta H, Ford-Hutchinson AW. Letts LG, et al. Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:1007-11. Adv Prostaglandin Thromboxane Leukot Res. 1987. PMID: 2960143 No abstract available.

4

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.

Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y. Delorme D, et al. Among authors: mcfarlane cs. J Med Chem. 1996 Sep 27;39(20):3951-70. doi: 10.1021/jm960301c. J Med Chem. 1996. PMID: 8831761

5

Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.

Ducharme Y, Brideau C, Dubé D, Chan CC, Falgueyret JP, Gillard JW, Guay J, Hutchinson JH, McFarlane CS, Riendeau D, et al. Ducharme Y, et al. Among authors: mcfarlane cs. J Med Chem. 1994 Feb 18;37(4):512-8. doi: 10.1021/jm00030a010. J Med Chem. 1994. PMID: 8120869

6

Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.

Hutchinson JH, Riendeau D, Brideau C, Chan C, Falgueyret JP, Guay J, Jones TR, Lépine C, Macdonald D, McFarlane CS, et al. Hutchinson JH, et al. Among authors: mcfarlane cs. J Med Chem. 1994 Apr 15;37(8):1153-64. doi: 10.1021/jm00034a013. J Med Chem. 1994. PMID: 8164257

7

Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.

Hutchinson JH, Charleson S, Evans JF, Falgueyret JP, Hoogsteen K, Jones TR, Kargman S, Macdonald D, McFarlane CS, Nicholson DW, et al. Hutchinson JH, et al. Among authors: mcfarlane cs. J Med Chem. 1995 Oct 27;38(22):4538-47. doi: 10.1021/jm00022a020. J Med Chem. 1995. PMID: 7473582

8

Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.

Hamel P, Riendeau D, Brideau C, Chan CC, Desmarais S, Delorme D, Dubé D, Ducharme Y, Ethier D, Grimm E, Falgueyret JP, Guay J, Jones TR, Kwong E, McAuliffe M, McFarlane CS, Piechuta H, Roumi M, Tagari P, Young RN, Girard Y. Hamel P, et al. Among authors: mcfarlane cs. J Med Chem. 1997 Aug 29;40(18):2866-75. doi: 10.1021/jm970046b. J Med Chem. 1997. PMID: 9288168

9

Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma.

Jones TR, McAuliffe M, McFarlane CS, Piechuta H, Macdonald D, Rodger IW. Jones TR, et al. Among authors: mcfarlane cs. Can J Physiol Pharmacol. 1998 Feb;76(2):210-7. Can J Physiol Pharmacol. 1998. PMID: 9635162

10

Late pulmonary responses induced by Ascaris allergen in conscious squirrel monkeys.

Hamel R, McFarlane CS, Ford-Hutchinson AW. Hamel R, et al. Among authors: mcfarlane cs. J Appl Physiol (1985). 1986 Dec;61(6):2081-7. doi: 10.1152/jappl.1986.61.6.2081. J Appl Physiol (1985). 1986. PMID: 3804916

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