Bartels T - Search Results

1

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Luth ES, et al. Among authors: bartels t. Biochemistry. 2015 Jan 20;54(2):279-92. doi: 10.1021/bi501188a. Epub 2014 Dec 23. Biochemistry. 2015. PMID: 25490121 Free PMC article.

2

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

Bartels T, Choi JG, Selkoe DJ. Bartels T, et al. Nature. 2011 Aug 14;477(7362):107-10. doi: 10.1038/nature10324. Nature. 2011. PMID: 21841800 Free PMC article.

3

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. Dettmer U, et al. Among authors: bartels t. J Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319586 Free PMC article.

We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicles more avidly than unfolded recombinant monomers (Bartels, T., Choi, J. G., and Selkoe, D. J. (2011) Nature 477, 107-110). Ho …

We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicl …

4

Defining the native state of α-synuclein.

Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Selkoe D, et al. Among authors: bartels t. Neurodegener Dis. 2014;13(2-3):114-7. doi: 10.1159/000355516. Epub 2013 Oct 30. Neurodegener Dis. 2014. PMID: 24192542 Review.

5

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Hong S, et al. Among authors: bartels t. Neuron. 2014 Apr 16;82(2):308-19. doi: 10.1016/j.neuron.2014.02.027. Epub 2014 Mar 27. Neuron. 2014. PMID: 24685176 Free PMC article.

6

Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

Luth ES, Stavrovskaya IG, Bartels T, Kristal BS, Selkoe DJ. Luth ES, et al. Among authors: bartels t. J Biol Chem. 2014 Aug 1;289(31):21490-507. doi: 10.1074/jbc.M113.545749. Epub 2014 Jun 18. J Biol Chem. 2014. PMID: 24942732 Free PMC article.

7

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.

Bartels T, Kim NC, Luth ES, Selkoe DJ. Bartels T, et al. PLoS One. 2014 Jul 30;9(7):e103727. doi: 10.1371/journal.pone.0103727. eCollection 2014. PLoS One. 2014. PMID: 25075858 Free PMC article.

8

ExPLAining early synucleinopathies.

Dettmer U, Bartels T. Dettmer U, et al. Among authors: bartels t. Brain. 2015 Jun;138(Pt 6):1449-51. doi: 10.1093/brain/awv099. Brain. 2015. PMID: 26013805 Free PMC article.

9

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Among authors: bartels t. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. Nat Commun. 2015. PMID: 26076669 Free PMC article.

10

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. Dettmer U, et al. Among authors: bartels t. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9596-601. doi: 10.1073/pnas.1505953112. Epub 2015 Jul 7. Proc Natl Acad Sci U S A. 2015. PMID: 26153422 Free PMC article.

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