Trotti D - Search Results

1

Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.

Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Wen X, et al. Among authors: trotti d. Neuron. 2014 Dec 17;84(6):1213-25. doi: 10.1016/j.neuron.2014.12.010. Neuron. 2014. PMID: 25521377 Free PMC article.

2

Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.

Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH Jr, Hediger MA. Trotti D, et al. J Biol Chem. 2001 Jan 5;276(1):576-82. doi: 10.1074/jbc.M003779200. J Biol Chem. 2001. PMID: 11031254 Free article.

3

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.

Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH Jr. Pasinelli P, et al. Among authors: trotti d. Neuron. 2004 Jul 8;43(1):19-30. doi: 10.1016/j.neuron.2004.06.021. Neuron. 2004. PMID: 15233914 Free article.

4

Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.

Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH Jr, Trotti D. Boston-Howes W, et al. Among authors: trotti d. J Biol Chem. 2006 May 19;281(20):14076-84. doi: 10.1074/jbc.M600653200. Epub 2006 Mar 27. J Biol Chem. 2006. PMID: 16567804 Free article.

5

A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.

Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH Jr, Pasinelli P, Trotti D. Gibb SL, et al. Among authors: trotti d. J Biol Chem. 2007 Nov 2;282(44):32480-90. doi: 10.1074/jbc.M704314200. Epub 2007 Sep 6. J Biol Chem. 2007. PMID: 17823119 Free article.

6

Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis.

Boston-Howes W, Williams EO, Bogush A, Scolere M, Pasinelli P, Trotti D. Boston-Howes W, et al. Among authors: trotti d. Exp Neurol. 2008 Sep;213(1):229-37. doi: 10.1016/j.expneurol.2008.06.010. Epub 2008 Jun 24. Exp Neurol. 2008. PMID: 18625223 Free PMC article.

7

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P. Pedrini S, et al. Among authors: trotti d. Hum Mol Genet. 2010 Aug 1;19(15):2974-86. doi: 10.1093/hmg/ddq202. Epub 2010 May 11. Hum Mol Genet. 2010. PMID: 20460269 Free PMC article.

8

Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria.

Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D. Fieni F, et al. Among authors: trotti d. J Biol Chem. 2010 Aug 27;285(35):27411-27417. doi: 10.1074/jbc.M110.131243. Epub 2010 Jun 15. J Biol Chem. 2010. PMID: 20551319 Free PMC article.

9

Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.

Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D. Foran E, et al. Among authors: trotti d. Glia. 2011 Nov;59(11):1719-31. doi: 10.1002/glia.21218. Epub 2011 Jul 18. Glia. 2011. PMID: 21769946 Free PMC article.

10

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.

Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P. Guareschi S, et al. Among authors: trotti d. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5074-9. doi: 10.1073/pnas.1115402109. Epub 2012 Mar 13. Proc Natl Acad Sci U S A. 2012. PMID: 22416121 Free PMC article.

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