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Page 1
Epigenetics: novel therapeutics targeting epigenetics.
Conway SJ, Woster PM, Shen JK, Georg G, Wang S. Conway SJ, et al. J Med Chem. 2015 Jan 22;58(2):523-4. doi: 10.1021/jm501941q. Epub 2014 Dec 22. J Med Chem. 2015. PMID: 25532017 No abstract available.
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, Brennan PE, Conway SJ. Hewings DS, et al. Among authors: conway sj. J Med Chem. 2013 Apr 25;56(8):3217-27. doi: 10.1021/jm301588r. Epub 2013 Apr 5. J Med Chem. 2013. PMID: 23517011 Free PMC article.
Epigenetics: Novel Therapeutics Targeting Epigenetics.
Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S. Conway SJ, et al. J Med Chem. 2016 Feb 25;59(4):1247-8. doi: 10.1021/acs.jmedchem.6b00098. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26824165 No abstract available.
Bifunctional Molecules beyond PROTACs.
Conway SJ. Conway SJ. J Med Chem. 2020 Mar 26;63(6):2802-2806. doi: 10.1021/acs.jmedchem.0c00293. Epub 2020 Mar 11. J Med Chem. 2020. PMID: 32157887
Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers.
Conway SJ, Arimondo P, Arrowsmith C, Jin J, Luo C, Meanwell N, Young W, Georg G, Wang S. Conway SJ, et al. J Med Chem. 2020 Nov 12;63(21):12129-12130. doi: 10.1021/acs.jmedchem.0c01748. Epub 2020 Oct 22. J Med Chem. 2020. PMID: 33090784 No abstract available.
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, Perell G, Kalra P, Vinh KB, Cortopassi WA, Heitel P, Christensen KE, Cooper RI, Paton RS, Pomerantz WCK, Biggin PC, Hammond EM, Filippakopoulos P, Conway SJ. Brand M, et al. Among authors: conway sj. J Med Chem. 2021 Jul 22;64(14):10102-10123. doi: 10.1021/acs.jmedchem.1c00348. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255515 Free PMC article.
Virtual Special Issue: Epigenetics 2022.
Aldrich CC, Calderón F, Conway SJ, He C, Hooker JM, Huryn DM, Lindsley CW, Liotta DC, Müller CE. Aldrich CC, et al. Among authors: conway sj. J Med Chem. 2022 Sep 22;65(18):11894-11899. doi: 10.1021/acs.jmedchem.2c01386. Epub 2022 Sep 8. J Med Chem. 2022. PMID: 36073827 No abstract available.
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ, Heightman TD. Hewings DS, et al. Among authors: conway sj. J Med Chem. 2011 Oct 13;54(19):6761-70. doi: 10.1021/jm200640v. Epub 2011 Sep 6. J Med Chem. 2011. PMID: 21851057 Free PMC article.
339 results