Upton RJ - Search Results

1

Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties.

Thansandote P, Harris RM, Dexter HL, Simpson GL, Pal S, Upton RJ, Valko K. Thansandote P, et al. Among authors: upton rj. Bioorg Med Chem. 2015 Jan 15;23(2):322-7. doi: 10.1016/j.bmc.2014.11.034. Epub 2014 Nov 28. Bioorg Med Chem. 2015. PMID: 25533323

2

Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series.

Barker M, Clackers M, Copley R, Demaine DA, Humphreys D, Inglis GG, Johnston MJ, Jones HT, Haase MV, House D, Loiseau R, Nisbet L, Pacquet F, Skone PA, Shanahan SE, Tape D, Vinader VM, Washington M, Uings I, Upton R, McLay IM, Macdonald SJ. Barker M, et al. J Med Chem. 2006 Jul 13;49(14):4216-31. doi: 10.1021/jm060302x. J Med Chem. 2006. PMID: 16821781

3

Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.

Macdonald SJ, Belton DJ, Buckley DM, Spooner JE, Anson MS, Harrison LA, Mills K, Upton RJ, Dowle MD, Smith RA, Molloy CR, Risley C. Macdonald SJ, et al. Among authors: upton rj. J Med Chem. 1998 Oct 8;41(21):3919-22. doi: 10.1021/jm981026s. J Med Chem. 1998. PMID: 9767628 No abstract available.

4

Synthesis of diverse macrocyclic peptidomimetics utilizing ring-closing metathesis and solid-phase synthesis.

Barrett AG, Hennessy AJ, Le Vézouët R, Procopiou PA, Seale PW, Stefaniak S, Upton RJ, White AJ, Williams DJ. Barrett AG, et al. Among authors: upton rj. J Org Chem. 2004 Feb 20;69(4):1028-37. doi: 10.1021/jo0352629. J Org Chem. 2004. PMID: 14961650

5

Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase.

Jones PS, Smith PW, Hardy GW, Howes PD, Upton RJ, Bethell RC. Jones PS, et al. Among authors: upton rj. Bioorg Med Chem Lett. 1999 Feb 22;9(4):605-10. doi: 10.1016/s0960-894x(99)00032-3. Bioorg Med Chem Lett. 1999. PMID: 10098673

6

Use of Calculated Physicochemical Properties to Enhance Quantitative Response When Using Charged Aerosol Detection.

Robinson MW, Hill AP, Readshaw SA, Hollerton JC, Upton RJ, Lynn SM, Besley SC, Boughtflower BJ. Robinson MW, et al. Among authors: upton rj. Anal Chem. 2017 Feb 7;89(3):1772-1777. doi: 10.1021/acs.analchem.6b04060. Epub 2017 Jan 17. Anal Chem. 2017. PMID: 28095671

7

The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin.

Murray PJ, Kranz M, Ladlow M, Taylor S, Berst F, Holmes AB, Keavey KN, Jaxa-Chamiec A, Seale PW, Stead P, Upton RJ, Croft SL, Clegg W, Elsegood MR. Murray PJ, et al. Among authors: upton rj. Bioorg Med Chem Lett. 2001 Mar 26;11(6):773-6. doi: 10.1016/s0960-894x(01)00049-x. Bioorg Med Chem Lett. 2001. PMID: 11277517

8

Solution, solid phase and computational structures of apicidin and its backbone-reduced analogs.

Kranz M, Murray PJ, Taylor S, Upton RJ, Clegg W, Elsegood MR. Kranz M, et al. Among authors: upton rj. J Pept Sci. 2006 Jun;12(6):383-8. doi: 10.1002/psc.738. J Pept Sci. 2006. PMID: 16342331

9

Rearrangement of a 16alpha,17alpha-Epoxy-16beta-methylandrostane-17beta-carbothioic Acid to a 17beta-Mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone.

Bain BM, Phillipps GH, Procopiou PA, Steeples IP, Upton RJ. Bain BM, et al. Among authors: upton rj. J Org Chem. 1998 Oct 16;63(21):7421-7424. doi: 10.1021/jo9812375. J Org Chem. 1998. PMID: 11672393

10

A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology.

Macdonald SJF, Clarke GDE, Dowle MD, Harrison LA, Hodgson ST, Inglis GGA, Johnson MR, Shah P, Upton RJ, Walls SB. Macdonald SJF, et al. Among authors: upton rj. J Org Chem. 1999 Jul 9;64(14):5166-5175. doi: 10.1021/jo990306s. J Org Chem. 1999. PMID: 34237863

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