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Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JK, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Ellison DW, Wharton SB, Robson K, Michalski A, Hargrave D, Jacques TS, Pizer B, Bailey S, Swartling FJ, Weiss WA, Chesler L, Clifford SC. Hill RM, et al. Among authors: wharton sb. Cancer Cell. 2015 Jan 12;27(1):72-84. doi: 10.1016/j.ccell.2014.11.002. Epub 2014 Dec 18. Cancer Cell. 2015. PMID: 25533335 Free PMC article.
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC. Schwalbe EC, et al. Among authors: wharton sb. Lancet Oncol. 2017 Jul;18(7):958-971. doi: 10.1016/S1470-2045(17)30243-7. Epub 2017 May 22. Lancet Oncol. 2017. PMID: 28545823 Free PMC article.
The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes.
Hicks D, Rafiee G, Schwalbe EC, Howell CI, Lindsey JC, Hill RM, Smith AJ, Adidharma P, Steel C, Richardson S, Pease L, Danilenko M, Crosier S, Joshi A, Wharton SB, Jacques TS, Pizer B, Michalski A, Williamson D, Bailey S, Clifford SC. Hicks D, et al. Among authors: wharton sb. Neuropathol Appl Neurobiol. 2021 Feb;47(2):236-250. doi: 10.1111/nan.12656. Epub 2020 Sep 1. Neuropathol Appl Neurobiol. 2021. PMID: 32779246 Free article.
Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study.
Hill RM, Richardson S, Schwalbe EC, Hicks D, Lindsey JC, Crosier S, Rafiee G, Grabovska Y, Wharton SB, Jacques TS, Michalski A, Joshi A, Pizer B, Williamson D, Bailey S, Clifford SC. Hill RM, et al. Among authors: wharton sb. Lancet Child Adolesc Health. 2020 Dec;4(12):865-874. doi: 10.1016/S2352-4642(20)30246-7. Epub 2020 Oct 22. Lancet Child Adolesc Health. 2020. PMID: 33222802 Free PMC article.
Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics.
Crosier S, Hicks D, Schwalbe EC, Williamson D, Leigh Nicholson S, Smith A, Lindsey JC, Michalski A, Pizer B, Bailey S, Bown N, Cuthbert G, Wharton SB, Jacques TS, Joshi A, Clifford SC. Crosier S, et al. Among authors: wharton sb. Neuropathol Appl Neurobiol. 2021 Oct;47(6):736-747. doi: 10.1111/nan.12716. Epub 2021 May 2. Neuropathol Appl Neurobiol. 2021. PMID: 33826763 Free PMC article.
Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse.
Richardson S, Hill RM, Kui C, Lindsey JC, Grabovksa Y, Keeling C, Pease L, Bashton M, Crosier S, Vinci M, André N, Figarella-Branger D, Hansford JR, Lastowska M, Zakrzewski K, Jorgensen M, Pickles JC, Taylor MD, Pfister SM, Wharton SB, Pizer B, Michalski A, Joshi A, Jacques TS, Hicks D, Schwalbe EC, Williamson D, Ramaswamy V, Bailey S, Clifford SC. Richardson S, et al. Among authors: wharton sb. Neuro Oncol. 2022 Jan 5;24(1):153-165. doi: 10.1093/neuonc/noab178. Neuro Oncol. 2022. PMID: 34272868 Free PMC article.
Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development.
Williamson D, Schwalbe EC, Hicks D, Aldinger KA, Lindsey JC, Crosier S, Richardson S, Goddard J, Hill RM, Castle J, Grabovska Y, Hacking J, Pizer B, Wharton SB, Jacques TS, Joshi A, Bailey S, Clifford SC. Williamson D, et al. Among authors: wharton sb. Cell Rep. 2022 Aug 2;40(5):111162. doi: 10.1016/j.celrep.2022.111162. Cell Rep. 2022. PMID: 35926460 Free PMC article.
Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.
Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE; MRC Cognitive Function and Ageing Neuropathology Study Group. Garwood C, et al. Among authors: wharton sb. Neuropathol Appl Neurobiol. 2013 Dec;39(7):788-99. doi: 10.1111/nan.12033. Neuropathol Appl Neurobiol. 2013. PMID: 23421725
176 results