Sawyers CL - Search Results

1

Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

Schwartz S, Wongvipat J, Trigwell CB, Hancox U, Carver BS, Rodrik-Outmezguine V, Will M, Yellen P, de Stanchina E, Baselga J, Scher HI, Barry ST, Sawyers CL, Chandarlapaty S, Rosen N. Schwartz S, et al. Among authors: sawyers cl. Cancer Cell. 2015 Jan 12;27(1):109-22. doi: 10.1016/j.ccell.2014.11.008. Epub 2014 Dec 24. Cancer Cell. 2015. PMID: 25544636 Free PMC article.

2

A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants.

Huron DR, Gorre ME, Kraker AJ, Sawyers CL, Rosen N, Moasser MM. Huron DR, et al. Among authors: sawyers cl. Clin Cancer Res. 2003 Apr;9(4):1267-73. Clin Cancer Res. 2003. PMID: 12684394

3

Myc-driven murine prostate cancer shares molecular features with human prostate tumors.

Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL. Ellwood-Yen K, et al. Among authors: sawyers cl. Cancer Cell. 2003 Sep;4(3):223-38. doi: 10.1016/s1535-6108(03)00197-1. Cancer Cell. 2003. PMID: 14522256 Free article.

4

HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.

Mellinghoff IK, Vivanco I, Kwon A, Tran C, Wongvipat J, Sawyers CL. Mellinghoff IK, et al. Among authors: sawyers cl. Cancer Cell. 2004 Nov;6(5):517-27. doi: 10.1016/j.ccr.2004.09.031. Cancer Cell. 2004. PMID: 15542435 Free article.

5

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis.

Scher HI, Sawyers CL. Scher HI, et al. Among authors: sawyers cl. J Clin Oncol. 2005 Nov 10;23(32):8253-61. doi: 10.1200/JCO.2005.03.4777. J Clin Oncol. 2005. PMID: 16278481 Review.

6

Context-dependent hormone-refractory progression revealed through characterization of a novel murine prostate cancer cell line.

Watson PA, Ellwood-Yen K, King JC, Wongvipat J, Lebeau MM, Sawyers CL. Watson PA, et al. Among authors: sawyers cl. Cancer Res. 2005 Dec 15;65(24):11565-71. doi: 10.1158/0008-5472.CAN-05-3441. Cancer Res. 2005. PMID: 16357166

7

Transgenic mouse model for rapid pharmacodynamic evaluation of antiandrogens.

Ellwood-Yen K, Wongvipat J, Sawyers C. Ellwood-Yen K, et al. Cancer Res. 2006 Nov 1;66(21):10513-6. doi: 10.1158/0008-5472.CAN-06-1397. Cancer Res. 2006. PMID: 17079473

8

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL. Vivanco I, et al. Among authors: sawyers cl. Cancer Cell. 2007 Jun;11(6):555-69. doi: 10.1016/j.ccr.2007.04.021. Cancer Cell. 2007. PMID: 17560336 Free article.

9

Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development.

Jiao J, Wang S, Qiao R, Vivanco I, Watson PA, Sawyers CL, Wu H. Jiao J, et al. Among authors: sawyers cl. Cancer Res. 2007 Jul 1;67(13):6083-91. doi: 10.1158/0008-5472.CAN-06-4202. Cancer Res. 2007. PMID: 17616663

10

Targeting the androgen receptor pathway in prostate cancer.

Chen Y, Sawyers CL, Scher HI. Chen Y, et al. Among authors: sawyers cl. Curr Opin Pharmacol. 2008 Aug;8(4):440-8. doi: 10.1016/j.coph.2008.07.005. Epub 2008 Aug 12. Curr Opin Pharmacol. 2008. PMID: 18674639 Free PMC article. Review.

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