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Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.
Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD. Buitrago Santanilla A, et al. Among authors: davies iw. Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20. Science. 2015. PMID: 25554781
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.
Greshock TJ, Moore KP, McClain RT, Bellomo A, Chung CK, Dreher SD, Kutchukian PS, Peng Z, Davies IW, Vachal P, Ellwart M, Manolikakes SM, Knochel P, Nantermet PG. Greshock TJ, et al. Among authors: davies iw. Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13714-13718. doi: 10.1002/anie.201604652. Epub 2016 Sep 30. Angew Chem Int Ed Engl. 2016. PMID: 27690172
Aryl amination using ligand-free Ni(II) salts and photoredox catalysis.
Corcoran EB, Pirnot MT, Lin S, Dreher SD, DiRocco DA, Davies IW, Buchwald SL, MacMillan DW. Corcoran EB, et al. Among authors: davies iw. Science. 2016 Jul 15;353(6296):279-83. doi: 10.1126/science.aag0209. Epub 2016 Jun 23. Science. 2016. PMID: 27338703 Free PMC article.
A multifunctional catalyst that stereoselectively assembles prodrugs.
DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. DiRocco DA, et al. Among authors: davies iw. Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936. Science. 2017. PMID: 28450641
126 results