Guzman ML - Search Results

1

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.

Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Penthala NR, et al. Among authors: guzman ml. Eur J Med Chem. 2015 Mar 6;92:212-20. doi: 10.1016/j.ejmech.2014.12.050. Epub 2014 Dec 29. Eur J Med Chem. 2015. PMID: 25557492 Free PMC article.

2

An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, Crooks PA, Jordan CT. Guzman ML, et al. Blood. 2007 Dec 15;110(13):4427-35. doi: 10.1182/blood-2007-05-090621. Epub 2007 Sep 5. Blood. 2007. PMID: 17804695 Free PMC article.

3

Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).

Neelakantan S, Nasim S, Guzman ML, Jordan CT, Crooks PA. Neelakantan S, et al. Among authors: guzman ml. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4346-9. doi: 10.1016/j.bmcl.2009.05.092. Epub 2009 May 27. Bioorg Med Chem Lett. 2009. PMID: 19505822

4

Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.

Hassane DC, Sen S, Minhajuddin M, Rossi RM, Corbett CA, Balys M, Wei L, Crooks PA, Guzman ML, Jordan CT. Hassane DC, et al. Among authors: guzman ml. Blood. 2010 Dec 23;116(26):5983-90. doi: 10.1182/blood-2010-04-278044. Epub 2010 Oct 1. Blood. 2010. PMID: 20889920 Free article.

5

Design, synthesis, and evaluation of small molecule Hsp90 probes.

Taldone T, Zatorska D, Patel PD, Zong H, Rodina A, Ahn JH, Moulick K, Guzman ML, Chiosis G. Taldone T, et al. Among authors: guzman ml. Bioorg Med Chem. 2011 Apr 15;19(8):2603-14. doi: 10.1016/j.bmc.2011.03.013. Epub 2011 Mar 12. Bioorg Med Chem. 2011. PMID: 21459002 Free PMC article. Review.

6

Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture.

Nasim S, Guzman ML, Jordan CT, Crooks PA. Nasim S, et al. Among authors: guzman ml. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4879-83. doi: 10.1016/j.bmcl.2011.06.027. Epub 2011 Jun 22. Bioorg Med Chem Lett. 2011. PMID: 21757349 Free PMC article.

7

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.

Taldone T, Gomes-DaGama EM, Zong H, Sen S, Alpaugh ML, Zatorska D, Alonso-Sabadell R, Guzman ML, Chiosis G. Taldone T, et al. Among authors: guzman ml. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5347-52. doi: 10.1016/j.bmcl.2011.07.026. Epub 2011 Jul 14. Bioorg Med Chem Lett. 2011. PMID: 21802945 Free PMC article.

8

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.

Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH. Illendula A, et al. Among authors: guzman ml. Science. 2015 Feb 13;347(6223):779-84. doi: 10.1126/science.aaa0314. Science. 2015. PMID: 25678665 Free PMC article.

9

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, Purohit T, Malik B, Zhao T, Wang J, Wen B, Zong H, Jones M, Danet-Desnoyers G, Guzman ML, Talpaz M, Bixby DL, Sun D, Hess JL, Muntean AG, Maillard I, Cierpicki T, Grembecka J. Borkin D, et al. Among authors: guzman ml. Cancer Cell. 2015 Apr 13;27(4):589-602. doi: 10.1016/j.ccell.2015.02.016. Epub 2015 Mar 26. Cancer Cell. 2015. PMID: 25817203 Free PMC article.

10

Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin.

Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Madadi NR, et al. Among authors: guzman ml. Medchemcomm. 2015 May 1;6(3):788-794. doi: 10.1039/C4MD00478G. Medchemcomm. 2015. PMID: 26257861 Free PMC article.

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