Obach RS - Search Results

1

Addressing the challenges of low clearance in drug research.

Di L, Obach RS. Di L, et al. Among authors: obach rs. AAPS J. 2015 Mar;17(2):352-7. doi: 10.1208/s12248-014-9691-7. Epub 2015 Jan 8. AAPS J. 2015. PMID: 25567366 Free PMC article. Review.

2

The prediction of human clearance from hepatic microsomal metabolism data.

Obach RS. Obach RS. Curr Opin Drug Discov Devel. 2001 Jan;4(1):36-44. Curr Opin Drug Discov Devel. 2001. PMID: 11727321 Review.

3

Reaction phenotyping in drug discovery: moving forward with confidence?

Williams JA, Hurst SI, Bauman J, Jones BC, Hyland R, Gibbs JP, Obach RS, Ball SE. Williams JA, et al. Among authors: obach rs. Curr Drug Metab. 2003 Dec;4(6):527-34. doi: 10.2174/1389200033489235. Curr Drug Metab. 2003. PMID: 14683480 Review.

4

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ. Obach RS, et al. Drug Metab Dispos. 2008 Jul;36(7):1385-405. doi: 10.1124/dmd.108.020479. Epub 2008 Apr 21. Drug Metab Dispos. 2008. PMID: 18426954

5

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: obach rs. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377

6

Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances.

Obach RS. Obach RS. Curr Opin Drug Discov Devel. 2009 Jan;12(1):81-9. Curr Opin Drug Discov Devel. 2009. PMID: 19152216

7

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.

Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS. Wang WW, et al. Among authors: obach rs. Drug Metab Dispos. 2010 Oct;38(10):1900-5. doi: 10.1124/dmd.110.034876. Epub 2010 Jul 1. Drug Metab Dispos. 2010. PMID: 20595376

8

Predicting clearance in humans from in vitro data.

Obach RS. Obach RS. Curr Top Med Chem. 2011;11(4):334-9. doi: 10.2174/156802611794480873. Curr Top Med Chem. 2011. PMID: 21320062 Review.

9

Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals.

Gao H, Obach RS. Gao H, et al. Among authors: obach rs. Curr Drug Metab. 2011 Jul;12(6):578-86. doi: 10.2174/138920011795713661. Curr Drug Metab. 2011. PMID: 21434861

10

Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events.

Shaffer CL, Scialis RJ, Rong H, Obach RS. Shaffer CL, et al. Among authors: obach rs. Biopharm Drug Dispos. 2012 Mar;33(2):72-84. doi: 10.1002/bdd.1768. Epub 2012 Jan 17. Biopharm Drug Dispos. 2012. PMID: 22213407

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