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The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.
Hoang B, Benavides A, Shi Y, Yang Y, Frost P, Gera J, Lichtenstein A. Hoang B, et al. Among authors: yang y. J Biol Chem. 2012 Jun 22;287(26):21796-805. doi: 10.1074/jbc.M111.304626. Epub 2012 May 3. J Biol Chem. 2012. PMID: 22556409 Free PMC article.
MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses.
Shi Y, Frost P, Hoang B, Yang Y, Bardeleben C, Gera J, Lichtenstein A. Shi Y, et al. Among authors: yang y. PLoS One. 2014 Apr 8;9(4):e94011. doi: 10.1371/journal.pone.0094011. eCollection 2014. PLoS One. 2014. Retraction in: PLoS One. 2023 Sep 8;18(9):e0291491. doi: 10.1371/journal.pone.0291491 PMID: 24714040 Free PMC article. Retracted.
PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing.
Liu B, Tahk S, Yee KM, Yang R, Yang Y, Mackie R, Hsu C, Chernishof V, O'Brien N, Jin Y, Fan G, Lane TF, Rao J, Slamon D, Shuai K. Liu B, et al. Among authors: yang r, yang y. PLoS One. 2014 Feb 24;9(2):e89464. doi: 10.1371/journal.pone.0089464. eCollection 2014. PLoS One. 2014. PMID: 24586797 Free PMC article.
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