Beaulieu PL - Search Results

1

Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite.

Beaulieu PL, Bolger G, Duplessis M, Gagnon A, Garneau M, Stammers T, Kukolj G, Duan J. Beaulieu PL, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1135-9. doi: 10.1016/j.bmcl.2014.12.028. Epub 2014 Dec 17. Bioorg Med Chem Lett. 2015. PMID: 25575656

2

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24. doi: 10.1016/j.bmcl.2003.10.023. Bioorg Med Chem Lett. 2004. PMID: 14684311

3

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Beaulieu PL, Bös M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, Gillard J, Goulet S, McKercher G, Poupart MA, Valois S, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):967-71. doi: 10.1016/j.bmcl.2003.12.032. Bioorg Med Chem Lett. 2004. PMID: 15013003

4

Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.

Beaulieu PL, Bousquet Y, Gauthier J, Gillard J, Marquis M, McKercher G, Pellerin C, Valois S, Kukolj G. Beaulieu PL, et al. J Med Chem. 2004 Dec 30;47(27):6884-92. doi: 10.1021/jm040134d. J Med Chem. 2004. PMID: 15615537

5

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93. doi: 10.1016/j.bmcl.2006.07.074. Bioorg Med Chem Lett. 2006. PMID: 16908138

6

Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization.

Goulet S, Poupart MA, Gillard J, Poirier M, Kukolj G, Beaulieu PL. Goulet S, et al. Among authors: beaulieu pl. Bioorg Med Chem Lett. 2010 Jan 1;20(1):196-200. doi: 10.1016/j.bmcl.2009.10.136. Epub 2009 Nov 4. Bioorg Med Chem Lett. 2010. PMID: 19945870

7

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

Beaulieu PL, Jolicoeur E, Gillard J, Brochu C, Coulombe R, Dansereau N, Duan J, Garneau M, Jakalian A, Kühn P, Lagacé L, LaPlante S, McKercher G, Perrault S, Poirier M, Poupart MA, Stammers T, Thauvette L, Thavonekham B, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):857-61. doi: 10.1016/j.bmcl.2009.12.101. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20074949

8

Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: improved drug-like properties through C-2 SAR in three sub-series.

Beaulieu PL, Dansereau N, Duan J, Garneau M, Gillard J, McKercher G, LaPlante S, Lagacée L, Thauvette L, Kukolj G. Beaulieu PL, et al. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1825-9. doi: 10.1016/j.bmcl.2010.02.003. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20185309

9

From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons.

Beaulieu PL, Gillard J, Jolicoeur E, Duan J, Garneau M, Kukolj G, Poupart MA. Beaulieu PL, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3658-63. doi: 10.1016/j.bmcl.2011.04.059. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21550240

10

Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.

Beaulieu PL, Chabot C, Duan J, Garneau M, Gillard J, Jolicoeur E, Poirier M, Poupart MA, Stammers TA, Kukolj G, Tsantrizos YS. Beaulieu PL, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3664-70. doi: 10.1016/j.bmcl.2011.04.082. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21592789

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