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The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.
Jaeger M, van der Lee R, Cheng SC, Johnson MD, Kumar V, Ng A, Plantinga TS, Smeekens SP, Oosting M, Wang X, Barchet W, Fitzgerald K, Joosten LAB, Perfect JR, Wijmenga C, van de Veerdonk FL, Huynen MA, Xavier RJ, Kullberg BJ, Netea MG. Jaeger M, et al. Among authors: smeekens sp. Eur J Clin Microbiol Infect Dis. 2015 May;34(5):963-974. doi: 10.1007/s10096-014-2309-2. Epub 2015 Jan 13. Eur J Clin Microbiol Infect Dis. 2015. PMID: 25579795 Free PMC article.
The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans.
Cheng SC, van de Veerdonk FL, Lenardon M, Stoffels M, Plantinga T, Smeekens S, Rizzetto L, Mukaremera L, Preechasuth K, Cavalieri D, Kanneganti TD, van der Meer JW, Kullberg BJ, Joosten LA, Gow NA, Netea MG. Cheng SC, et al. J Leukoc Biol. 2011 Aug;90(2):357-66. doi: 10.1189/jlb.1210702. Epub 2011 Apr 29. J Leukoc Biol. 2011. PMID: 21531876 Free PMC article.
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis.
van de Veerdonk FL, Plantinga TS, Hoischen A, Smeekens SP, Joosten LA, Gilissen C, Arts P, Rosentul DC, Carmichael AJ, Smits-van der Graaf CA, Kullberg BJ, van der Meer JW, Lilic D, Veltman JA, Netea MG. van de Veerdonk FL, et al. Among authors: smeekens sp. N Engl J Med. 2011 Jul 7;365(1):54-61. doi: 10.1056/NEJMoa1100102. Epub 2011 Jun 29. N Engl J Med. 2011. PMID: 21714643 Free article.
STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis.
Smeekens SP, Plantinga TS, van de Veerdonk FL, Heinhuis B, Hoischen A, Joosten LA, Arkwright PD, Gennery A, Kullberg BJ, Veltman JA, Lilic D, van der Meer JW, Netea MG. Smeekens SP, et al. PLoS One. 2011;6(12):e29248. doi: 10.1371/journal.pone.0029248. Epub 2011 Dec 14. PLoS One. 2011. PMID: 22195034 Free PMC article.
77 results