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Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-beta-trypsin complex.
Sreedharan SK, Verma C, Caves LS, Brocklehurst SM, Gharbia SE, Shah HN, Brocklehurst K. Sreedharan SK, et al. Biochem J. 1996 Jun 15;316 ( Pt 3)(Pt 3):777-86. doi: 10.1042/bj3160777. Biochem J. 1996. PMID: 8670152 Free PMC article.
335 results