Wilderman PR - Search Results

1

Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.

Shah MB, Wilderman PR, Liu J, Jang HH, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: wilderman pr. Mol Pharmacol. 2015 Apr;87(4):649-59. doi: 10.1124/mol.114.097014. Epub 2015 Jan 13. Mol Pharmacol. 2015. PMID: 25585967 Free PMC article.

2

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Among authors: wilderman pr. Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8. Mol Pharmacol. 2010. PMID: 20061448 Free PMC article.

3

Plasticity of CYP2B enzymes: structural and solution biophysical methods.

Wilderman PR, Halpert JR. Wilderman PR, et al. Curr Drug Metab. 2012 Feb;13(2):167-76. doi: 10.2174/138920012798918417. Curr Drug Metab. 2012. PMID: 22208531 Free PMC article. Review.

4

Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: wilderman pr. Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4. Biochemistry. 2012. PMID: 22909231 Free PMC article.

5

Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6.

Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR. Wilderman PR, et al. J Am Chem Soc. 2013 Jul 17;135(28):10433-40. doi: 10.1021/ja403042k. Epub 2013 Jul 3. J Am Chem Soc. 2013. PMID: 23786449 Free PMC article.

6

Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.

Wilderman PR, Jang HH, Malenke JR, Salib M, Angermeier E, Lamime S, Dearing MD, Halpert JR. Wilderman PR, et al. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):393-401. doi: 10.1016/j.taap.2013.12.005. Epub 2013 Dec 19. Toxicol Appl Pharmacol. 2014. PMID: 24361551 Free PMC article.

7

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism.

Shah MB, Liu J, Huo L, Zhang Q, Dearing MD, Wilderman PR, Szklarz GD, Stout CD, Halpert JR. Shah MB, et al. Among authors: wilderman pr. Mol Pharmacol. 2016 Apr;89(4):435-45. doi: 10.1124/mol.115.102111. Epub 2016 Jan 29. Mol Pharmacol. 2016. PMID: 26826176 Free PMC article.

8

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.

Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR. Liu J, et al. Among authors: wilderman pr. Biochemistry. 2016 Apr 5;55(13):1997-2007. doi: 10.1021/acs.biochem.5b01330. Epub 2016 Mar 24. Biochemistry. 2016. PMID: 26982502 Free PMC article.

9

Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.

Shah MB, Jang HH, Wilderman PR, Lee D, Li S, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: wilderman pr. Biophys Chem. 2016 Sep;216:1-8. doi: 10.1016/j.bpc.2016.05.007. Epub 2016 Jun 1. Biophys Chem. 2016. PMID: 27280734 Free PMC article.

10

Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.

Jang HH, Liu J, Lee GY, Halpert JR, Wilderman PR. Jang HH, et al. Among authors: wilderman pr. Arch Biochem Biophys. 2015 Oct 15;584:61-9. doi: 10.1016/j.abb.2015.08.007. Epub 2015 Aug 28. Arch Biochem Biophys. 2015. PMID: 26319176 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

27 results

Search Page

Filters