Baer MR - Search Results

1

The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations.

Mathias TJ, Natarajan K, Shukla S, Doshi KA, Singh ZN, Ambudkar SV, Baer MR. Mathias TJ, et al. Among authors: baer mr. Invest New Drugs. 2015 Apr;33(2):300-9. doi: 10.1007/s10637-015-0205-y. Epub 2015 Jan 20. Invest New Drugs. 2015. PMID: 25597754 Free PMC article.

2

Differential effects of the immunosuppressive agents cyclosporin A, tacrolimus and sirolimus on drug transport by multidrug resistance proteins.

Pawarode A, Shukla S, Minderman H, Fricke SM, Pinder EM, O'Loughlin KL, Ambudkar SV, Baer MR. Pawarode A, et al. Among authors: baer mr. Cancer Chemother Pharmacol. 2007 Jul;60(2):179-88. doi: 10.1007/s00280-006-0357-8. Epub 2006 Oct 10. Cancer Chemother Pharmacol. 2007. PMID: 17031644

3

The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.

Brooks TA, O'Loughlin KL, Minderman H, Bundy BN, Ford LA, Vredenburg MR, Bernacki RJ, Priebe W, Baer MR. Brooks TA, et al. Among authors: baer mr. Invest New Drugs. 2007 Apr;25(2):115-22. doi: 10.1007/s10637-006-9018-3. Epub 2006 Oct 28. Invest New Drugs. 2007. PMID: 17072745

4

Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance.

Natarajan K, Xie Y, Baer MR, Ross DD. Natarajan K, et al. Among authors: baer mr. Biochem Pharmacol. 2012 Apr 15;83(8):1084-103. doi: 10.1016/j.bcp.2012.01.002. Epub 2012 Jan 11. Biochem Pharmacol. 2012. PMID: 22248732 Free PMC article. Review.

5

The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2.

Sen R, Natarajan K, Bhullar J, Shukla S, Fang HB, Cai L, Chen ZS, Ambudkar SV, Baer MR. Sen R, et al. Among authors: baer mr. Mol Cancer Ther. 2012 Sep;11(9):2033-44. doi: 10.1158/1535-7163.MCT-12-0302. Epub 2012 Jul 9. Mol Cancer Ther. 2012. PMID: 22778153 Free PMC article.

6

The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.

Natarajan K, Bhullar J, Shukla S, Burcu M, Chen ZS, Ambudkar SV, Baer MR. Natarajan K, et al. Among authors: baer mr. Biochem Pharmacol. 2013 Feb 15;85(4):514-24. doi: 10.1016/j.bcp.2012.12.006. Epub 2012 Dec 19. Biochem Pharmacol. 2013. PMID: 23261525 Free PMC article.

7

Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome.

Gojo I, Perl A, Luger S, Baer MR, Norsworthy KJ, Bauer KS, Tidwell M, Fleckinger S, Carroll M, Sausville EA. Gojo I, et al. Among authors: baer mr. Invest New Drugs. 2013 Oct;31(5):1217-27. doi: 10.1007/s10637-013-9937-8. Epub 2013 Feb 27. Invest New Drugs. 2013. PMID: 23443507 Free PMC article. Clinical Trial.

8

The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions.

Bhullar J, Natarajan K, Shukla S, Mathias TJ, Sadowska M, Ambudkar SV, Baer MR. Bhullar J, et al. Among authors: baer mr. PLoS One. 2013 Aug 14;8(8):e71266. doi: 10.1371/journal.pone.0071266. eCollection 2013. PLoS One. 2013. PMID: 23967177 Free PMC article.

9

Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication.

Natarajan K, Xie Y, Burcu M, Linn DE, Qiu Y, Baer MR. Natarajan K, et al. Among authors: baer mr. PLoS One. 2013 Sep 5;8(9):e74653. doi: 10.1371/journal.pone.0074653. eCollection 2013. PLoS One. 2013. PMID: 24040307 Free PMC article.

10

Ponatinib enhances anticancer drug sensitivity in MRP7-overexpressing cells.

Sun YL, Kumar P, Sodani K, Patel A, Pan Y, Baer MR, Chen ZS, Jiang WQ. Sun YL, et al. Among authors: baer mr. Oncol Rep. 2014 Apr;31(4):1605-12. doi: 10.3892/or.2014.3002. Epub 2014 Jan 28. Oncol Rep. 2014. PMID: 24481648 Free PMC article.

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