Tonge PJ - Search Results

1

A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA.

Perryman AL, Yu W, Wang X, Ekins S, Forli S, Li SG, Freundlich JS, Tonge PJ, Olson AJ. Perryman AL, et al. Among authors: tonge pj. J Chem Inf Model. 2015 Mar 23;55(3):645-59. doi: 10.1021/ci500672v. Epub 2015 Feb 17. J Chem Inf Model. 2015. PMID: 25636146 Free PMC article.

2

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.

Rawat R, Whitty A, Tonge PJ. Rawat R, et al. Among authors: tonge pj. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13881-6. doi: 10.1073/pnas.2235848100. Epub 2003 Nov 17. Proc Natl Acad Sci U S A. 2003. PMID: 14623976 Free PMC article.

3

High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.

Sullivan TJ, Truglio JJ, Boyne ME, Novichenok P, Zhang X, Stratton CF, Li HJ, Kaur T, Amin A, Johnson F, Slayden RA, Kisker C, Tonge PJ. Sullivan TJ, et al. Among authors: tonge pj. ACS Chem Biol. 2006 Feb 17;1(1):43-53. doi: 10.1021/cb0500042. ACS Chem Biol. 2006. PMID: 17163639

4

Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis.

Tonge PJ, Kisker C, Slayden RA. Tonge PJ, et al. Curr Top Med Chem. 2007;7(5):489-98. doi: 10.2174/156802607780059781. Curr Top Med Chem. 2007. PMID: 17346194 Review.

5

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.

am Ende CW, Knudson SE, Liu N, Childs J, Sullivan TJ, Boyne M, Xu H, Gegina Y, Knudson DL, Johnson F, Peloquin CA, Slayden RA, Tonge PJ. am Ende CW, et al. Among authors: tonge pj. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. doi: 10.1016/j.bmcl.2008.04.038. Epub 2008 Apr 18. Bioorg Med Chem Lett. 2008. PMID: 18457948 Free PMC article.

6

A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis.

Luckner SR, Liu N, am Ende CW, Tonge PJ, Kisker C. Luckner SR, et al. Among authors: tonge pj. J Biol Chem. 2010 May 7;285(19):14330-7. doi: 10.1074/jbc.M109.090373. Epub 2010 Mar 3. J Biol Chem. 2010. PMID: 20200152 Free PMC article.

7

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ. Li X, et al. Among authors: tonge pj. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6306-9. doi: 10.1016/j.bmcl.2010.08.076. Epub 2010 Aug 21. Bioorg Med Chem Lett. 2010. PMID: 20850304 Free PMC article.

8

Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.

Pan P, Tonge PJ. Pan P, et al. Among authors: tonge pj. Curr Top Med Chem. 2012;12(7):672-93. doi: 10.2174/156802612799984535. Curr Top Med Chem. 2012. PMID: 22283812 Free PMC article. Review.

9

Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.

Chang A, Schiebel J, Yu W, Bommineni GR, Pan P, Baxter MV, Khanna A, Sotriffer CA, Kisker C, Tonge PJ. Chang A, et al. Among authors: tonge pj. Biochemistry. 2013 Jun 18;52(24):4217-28. doi: 10.1021/bi400413c. Epub 2013 Jun 6. Biochemistry. 2013. PMID: 23697754 Free PMC article.

10

Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.

Cummings JE, Beaupre AJ, Knudson SE, Liu N, Yu W, Neckles C, Wang H, Khanna A, Bommineni GR, Trunck LA, Schweizer HP, Tonge PJ, Slayden RA. Cummings JE, et al. Among authors: tonge pj. Antimicrob Agents Chemother. 2014;58(3):1646-51. doi: 10.1128/AAC.02296-13. Epub 2013 Dec 30. Antimicrob Agents Chemother. 2014. PMID: 24379198 Free PMC article.

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