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Safety, Tolerability, and Pharmacokinetics of SMT C1100, a 2-Arylbenzoxazole Utrophin Modulator, following Single- and Multiple-Dose Administration to Pediatric Patients with Duchenne Muscular Dystrophy.
Ricotti V, Spinty S, Roper H, Hughes I, Tejura B, Robinson N, Layton G, Davies K, Muntoni F, Tinsley J. Ricotti V, et al. Among authors: robinson n. PLoS One. 2016 Apr 7;11(4):e0152840. doi: 10.1371/journal.pone.0152840. eCollection 2016. PLoS One. 2016. PMID: 27055247 Free PMC article. Clinical Trial.
2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.
Babbs A, Berg A, Chatzopoulou M, Davies KE, Davies SG, Edwards B, Elsey DJ, Emer E, Guiraud S, Harriman S, Lecci C, Moir L, Peters D, Robinson N, Rowley JA, Russell AJ, Squire SE, Tinsley JM, Wilson FX, Wynne GM. Babbs A, et al. Among authors: robinson n. J Med Chem. 2020 Jul 23;63(14):7880-7891. doi: 10.1021/acs.jmedchem.0c00807. Epub 2020 Jul 10. J Med Chem. 2020. PMID: 32551645
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Chatzopoulou M, Claridge TDW, Davies KE, Davies SG, Elsey DJ, Emer E, Fletcher AM, Harriman S, Robinson N, Rowley JA, Russell AJ, Tinsley JM, Weaver R, Wilkinson IVL, Willis NJ, Wilson FX, Wynne GM. Chatzopoulou M, et al. Among authors: robinson n. J Med Chem. 2020 Mar 12;63(5):2547-2556. doi: 10.1021/acs.jmedchem.9b01547. Epub 2019 Oct 25. J Med Chem. 2020. PMID: 31599580
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.
Babbs A, Berg A, Chatzopoulou M, Davies KE, Davies SG, Edwards B, Elsey DJ, Emer E, Figuccia ALA, Fletcher AM, Guiraud S, Harriman S, Moir L, Robinson N, Rowley JA, Russell AJ, Squire SE, Thomson JE, Tinsley JM, Wilson FX, Wynne GM. Babbs A, et al. Among authors: robinson n. Tetrahedron. 2020 Jan 10;76(2):130819. doi: 10.1016/j.tet.2019.130819. Tetrahedron. 2020. PMID: 32713969 Free PMC article.
A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections.
Vickers R, Robinson N, Best E, Echols R, Tillotson G, Wilcox M. Vickers R, et al. Among authors: robinson n. BMC Infect Dis. 2015 Feb 25;15:91. doi: 10.1186/s12879-015-0759-5. BMC Infect Dis. 2015. PMID: 25880933 Free PMC article. Clinical Trial.
1,910 results