Van Goethem F - Search Results

1

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

Mesens N, Crawford AD, Menke A, Hung PD, Van Goethem F, Nuyts R, Hansen E, Wolterbeek A, Van Gompel J, De Witte P, Esguerra CV. Mesens N, et al. Among authors: van goethem f. J Appl Toxicol. 2015 Sep;35(9):1017-29. doi: 10.1002/jat.3091. Epub 2015 Feb 6. J Appl Toxicol. 2015. PMID: 25663337

2

Screening for phospholipidosis induced by central nervous drugs: comparing the predictivity of an in vitro assay to high throughput in silico assays.

Mesens N, Steemans M, Hansen E, Verheyen GR, Van Goethem F, Van Gompel J. Mesens N, et al. Among authors: van goethem f, van gompel j. Toxicol In Vitro. 2010 Aug;24(5):1417-25. doi: 10.1016/j.tiv.2010.04.007. Epub 2010 Apr 27. Toxicol In Vitro. 2010. PMID: 20430096

3

Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay.

Van Goethem F, Hansen E, Sysmans M, De Smedt A, Vanparys P, Van Gompel J. Van Goethem F, et al. Among authors: van gompel j. Toxicol In Vitro. 2010 Sep;24(6):1854-61. doi: 10.1016/j.tiv.2010.04.012. Epub 2010 May 5. Toxicol In Vitro. 2010. PMID: 20450968

4

Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals.

Van Goethem F, Adriaens E, Alépée N, Straube F, De Wever B, Cappadoro M, Catoire S, Hansen E, Wolf A, Vanparys P. Van Goethem F, et al. Toxicol In Vitro. 2006 Feb;20(1):1-17. doi: 10.1016/j.tiv.2005.05.002. Epub 2005 Jul 12. Toxicol In Vitro. 2006. PMID: 16019187

5

Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.

Verbist BM, Verheyen GR, Vervoort L, Crabbe M, Beerens D, Bosmans C, Jaensch S, Osselaer S, Talloen W, Van den Wyngaert I, Van Hecke G, Wuyts D; QSTAR Consortium; Van Goethem F, Göhlmann HW. Verbist BM, et al. Among authors: van goethem f. Chem Res Toxicol. 2015 Oct 19;28(10):1914-25. doi: 10.1021/acs.chemrestox.5b00103. Epub 2015 Sep 15. Chem Res Toxicol. 2015. PMID: 26313431 Free article.

6

Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells.

De Smedt A, Steemans M, De Boeck M, Peters AK, van der Leede BJ, Van Goethem F, Lampo A, Vanparys P. De Smedt A, et al. Among authors: van goethem f, van der leede bj. Toxicol In Vitro. 2008 Oct;22(7):1789-96. doi: 10.1016/j.tiv.2008.07.003. Epub 2008 Jul 11. Toxicol In Vitro. 2008. PMID: 18672049

7

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay.

Bryce SM, Avlasevich SL, Bemis JC, Lukamowicz M, Elhajouji A, Van Goethem F, De Boeck M, Beerens D, Aerts H, Van Gompel J, Collins JE, Ellis PC, White AT, Lynch AM, Dertinger SD. Bryce SM, et al. Among authors: van goethem f, van gompel j. Mutat Res. 2008 Feb 29;650(2):181-95. doi: 10.1016/j.mrgentox.2007.11.006. Epub 2007 Nov 29. Mutat Res. 2008. PMID: 18182318 Free PMC article.

8

Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling.

De Boeck M, van der Leede BJ, Van Goethem F, De Smedt A, Steemans M, Lampo A, Vanparys P. De Boeck M, et al. Among authors: van goethem f, van der leede bj. Environ Mol Mutagen. 2005 Jul;46(1):30-42. doi: 10.1002/em.20127. Environ Mol Mutagen. 2005. PMID: 15880423

9

Methods to evaluate and improve the injection site tolerability of intravenous formulations prior to first-in-human testing.

Eichenbaum G, Zhou J, De Smedt A, De Jonghe S, Looszova A, Arien T, Van Goethem F, Vervoort I, Shukla U, Lammens L. Eichenbaum G, et al. Among authors: van goethem f. J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):394-406. doi: 10.1016/j.vascn.2013.08.002. Epub 2013 Aug 8. J Pharmacol Toxicol Methods. 2013. PMID: 23933112

10

Cosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation.

Alépée N, Bessou-Touya S, Cotovio J, de Smedt A, de Wever B, Faller C, Jones P, Le Varlet B, Marrec-Fairley M, Pfannenbecker U, Tailhardat M, van Goethem F, McNamee P. Alépée N, et al. Among authors: van goethem f. Toxicol In Vitro. 2013 Aug;27(5):1476-88. doi: 10.1016/j.tiv.2013.02.009. Epub 2013 Mar 20. Toxicol In Vitro. 2013. PMID: 23524228

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