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Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.
Sprague JL, Schille TB, Allert S, Trümper V, Lier A, Großmann P, Priest EL, Tsavou A, Panagiotou G, Naglik JR, Wilson D, Schäuble S, Kasper L, Hube B. Sprague JL, et al. Among authors: naglik jr. PLoS Pathog. 2024 Mar 1;20(3):e1012031. doi: 10.1371/journal.ppat.1012031. eCollection 2024 Mar. PLoS Pathog. 2024. PMID: 38427950 Free PMC article.
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis.
Valentine M, Rudolph P, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS, Hube B. Valentine M, et al. Among authors: naglik jr. mBio. 2024 Mar 13;15(3):e0340923. doi: 10.1128/mbio.03409-23. Epub 2024 Feb 13. mBio. 2024. PMID: 38349176 Free PMC article.
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences.
Müller R, König A, Groth S, Zarnowski R, Visser C, Handrianz T, Maufrais C, Krüger T, Himmel M, Lee S, Priest EL, Yildirim D, Richardson JP, Blango MG, Bougnoux ME, Kniemeyer O, d'Enfert C, Brakhage AA, Andes DR, Trümper V, Nehls C, Kasper L, Mogavero S, Gutsmann T, Naglik JR, Allert S, Hube B. Müller R, et al. Among authors: naglik jr. Nat Microbiol. 2024 Mar;9(3):669-683. doi: 10.1038/s41564-024-01606-z. Epub 2024 Feb 22. Nat Microbiol. 2024. PMID: 38388771
107 results