Peng X - Search Results

1

Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.

Ma Y, Sun G, Chen D, Peng X, Chen YL, Su Y, Ji Y, Liang J, Wang X, Chen L, Ding J, Xiong B, Ai J, Geng M, Shen J. Ma Y, et al. Among authors: peng x. J Med Chem. 2015 Mar 12;58(5):2513-29. doi: 10.1021/jm502018y. Epub 2015 Feb 25. J Med Chem. 2015. PMID: 25668160

2

Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors.

Zhang D, Ai J, Liang Z, Li C, Peng X, Ji Y, Jiang H, Geng M, Luo C, Liu H. Zhang D, et al. Among authors: peng x. Bioorg Med Chem. 2012 Sep 1;20(17):5169-80. doi: 10.1016/j.bmc.2012.07.007. Epub 2012 Jul 16. Bioorg Med Chem. 2012. PMID: 22863529

3

Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: synthesis and SAR study as tyrosine kinase c-Met inhibitors.

Wu K, Ai J, Liu Q, Chen T, Zhao A, Peng X, Wang Y, Ji Y, Yao Q, Xu Y, Geng M, Zhang A. Wu K, et al. Among authors: peng x. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6368-72. doi: 10.1016/j.bmcl.2012.08.075. Epub 2012 Aug 27. Bioorg Med Chem Lett. 2012. PMID: 22985853

4

Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors.

Wang Y, Xu ZL, Ai J, Peng X, Lin JP, Ji YC, Geng MY, Long YQ. Wang Y, et al. Among authors: peng x. Org Biomol Chem. 2013 Mar 7;11(9):1545-62. doi: 10.1039/c2ob26710a. Org Biomol Chem. 2013. PMID: 23188156

5

Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.

Zhang D, Ai J, Liang Z, Zhu W, Peng X, Chen X, Ji Y, Jiang H, Luo C, Geng M, Liu H. Zhang D, et al. Among authors: peng x. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2408-13. doi: 10.1016/j.bmcl.2013.02.037. Epub 2013 Feb 14. Bioorg Med Chem Lett. 2013. PMID: 23474386

6

Discovery of novel c-Met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold.

Zhang W, Ai J, Shi D, Peng X, Ji Y, Liu J, Geng M, Li Y. Zhang W, et al. Among authors: peng x. Molecules. 2014 Feb 24;19(2):2655-73. doi: 10.3390/molecules19022655. Molecules. 2014. PMID: 24566328 Free PMC article.

7

Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors.

Xu J, Ai J, Liu S, Peng X, Yu L, Geng M, Nan F. Xu J, et al. Among authors: peng x. Org Biomol Chem. 2014 Jun 14;12(22):3721-34. doi: 10.1039/c4ob00364k. Epub 2014 Apr 30. Org Biomol Chem. 2014. PMID: 24781551

8

Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases.

Song Z, Yang Y, Liu Z, Peng X, Guo J, Yang X, Wu K, Ai J, Ding J, Geng M, Zhang A. Song Z, et al. Among authors: peng x. J Med Chem. 2015 Jan 8;58(1):197-211. doi: 10.1021/jm5005144. Epub 2014 May 8. J Med Chem. 2015. PMID: 24785465

9

Discovery of novel type II c-Met inhibitors based on BMS-777607.

Zhang W, Ai J, Shi D, Peng X, Ji Y, Liu J, Geng M, Li Y. Zhang W, et al. Among authors: peng x. Eur J Med Chem. 2014 Jun 10;80:254-66. doi: 10.1016/j.ejmech.2014.04.056. Epub 2014 Apr 21. Eur J Med Chem. 2014. PMID: 24792774

10

SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo.

Wang L, Ai J, Shen Y, Zhang H, Peng X, Huang M, Zhang A, Ding J, Geng M. Wang L, et al. Among authors: peng x. Cancer Lett. 2014 Aug 28;351(1):143-50. doi: 10.1016/j.canlet.2014.05.012. Epub 2014 May 28. Cancer Lett. 2014. PMID: 24880078

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