Oyarzabal J - Search Results

1

Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.

Orbe J, Sánchez-Arias JA, Rabal O, Rodríguez JA, Salicio A, Ugarte A, Belzunce M, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J. Orbe J, et al. Among authors: oyarzabal j. J Med Chem. 2015 Mar 12;58(5):2465-88. doi: 10.1021/jm501940y. Epub 2015 Feb 25. J Med Chem. 2015. PMID: 25686153

2

ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1. An NMR characterization.

Zimmerman T, Oyarzabal J, Sebastián ES, Majumdar S, Tejo BA, Siahaan TJ, Blanco FJ. Zimmerman T, et al. Among authors: oyarzabal j. Chem Biol Drug Des. 2007 Oct;70(4):347-53. doi: 10.1111/j.1747-0285.2007.00566.x. Epub 2007 Sep 14. Chem Biol Drug Des. 2007. PMID: 17868072

3

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases.

Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebriá A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soilán D, Ceballos PA, Hernández AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR. Link W, et al. Among authors: oyarzabal j. J Biol Chem. 2009 Oct 9;284(41):28392-28400. doi: 10.1074/jbc.M109.038984. Epub 2009 Aug 18. J Biol Chem. 2009. PMID: 19690175 Free PMC article.

4

An integrated one-step system to extract, analyze and annotate all relevant information from image-based cell screening of chemical libraries.

Rabal O, Link W, Serelde BG, Bischoff JR, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. Mol Biosyst. 2010 Apr;6(4):711-20. doi: 10.1039/b919830j. Epub 2010 Jan 21. Mol Biosyst. 2010. PMID: 20237649

5

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

Oyarzabal J, Zarich N, Albarran MI, Palacios I, Urbano-Cuadrado M, Mateos G, Reymundo I, Rabal O, Salgado A, Corrionero A, Fominaya J, Pastor J, Bischoff JR. Oyarzabal J, et al. J Med Chem. 2010 Sep 23;53(18):6618-28. doi: 10.1021/jm1005513. J Med Chem. 2010. PMID: 20722422

6

Centralizing discovery information: from logistics to knowledge at a public organization.

Urbano-Cuadrado M, Rabal O, Oyarzabal J. Urbano-Cuadrado M, et al. Among authors: oyarzabal j. Comb Chem High Throughput Screen. 2011 Jul;14(6):429-49. doi: 10.2174/138620711795767848. Comb Chem High Throughput Screen. 2011. PMID: 21143181

7

Computational medicinal chemistry in fragment-based drug discovery: what, how and when.

Rabal O, Urbano-Cuadrado M, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. Future Med Chem. 2011 Jan;3(1):95-134. doi: 10.4155/fmc.10.277. Future Med Chem. 2011. PMID: 21428828 Review.

8

Conformational selection versus induced fit in kinases: the case of PI3K-γ.

D'Abramo M, Rabal O, Oyarzabal J, Gervasio FL. D'Abramo M, et al. Among authors: oyarzabal j. Angew Chem Int Ed Engl. 2012 Jan 16;51(3):642-6. doi: 10.1002/anie.201103264. Epub 2011 Dec 1. Angew Chem Int Ed Engl. 2012. PMID: 22135005 No abstract available.

9

Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.

Cuadrado-Tejedor M, García-Osta A, Ricobaraza A, Oyarzabal J, Franco R. Cuadrado-Tejedor M, et al. Among authors: oyarzabal j. Curr Med Chem. 2011;18(36):5545-53. doi: 10.2174/092986711798347315. Curr Med Chem. 2011. PMID: 22172064 Free article. Review.

10

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.

Pastor J, Oyarzabal J, Saluste G, Alvarez RM, Rivero V, Ramos F, Cendón E, Blanco-Aparicio C, Ajenjo N, Cebriá A, Albarrán MI, Cebrián D, Corrionero A, Fominaya J, Montoya G, Mazzorana M. Pastor J, et al. Among authors: oyarzabal j. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1591-7. doi: 10.1016/j.bmcl.2011.12.130. Epub 2012 Jan 5. Bioorg Med Chem Lett. 2012. PMID: 22266039

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