Harada-Shiba M - Search Results

1

Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo.

Yamamoto T, Yahara A, Waki R, Yasuhara H, Wada F, Harada-Shiba M, Obika S. Yamamoto T, et al. Org Biomol Chem. 2015 Mar 28;13(12):3757-65. doi: 10.1039/c5ob00242g. Org Biomol Chem. 2015. PMID: 25690587

2

Efficient reduction of serum cholesterol by combining a liver-targeted gene delivery system with chemically modified apolipoprotein B siRNA.

Kang JH, Tachibana Y, Obika S, Harada-Shiba M, Yamaoka T. Kang JH, et al. J Control Release. 2012 Oct 28;163(2):119-24. doi: 10.1016/j.jconrel.2012.08.030. Epub 2012 Sep 4. J Control Release. 2012. PMID: 22974833

3

Superior Silencing by 2',4'-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors.

Yamamoto T, Yasuhara H, Wada F, Harada-Shiba M, Imanishi T, Obika S. Yamamoto T, et al. J Nucleic Acids. 2012;2012:707323. doi: 10.1155/2012/707323. Epub 2012 Sep 26. J Nucleic Acids. 2012. PMID: 23056920 Free PMC article.

4

Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice.

Yamamoto T, Harada-Shiba M, Nakatani M, Wada S, Yasuhara H, Narukawa K, Sasaki K, Shibata MA, Torigoe H, Yamaoka T, Imanishi T, Obika S. Yamamoto T, et al. Mol Ther Nucleic Acids. 2012 May 15;1(5):e22. doi: 10.1038/mtna.2012.16. Mol Ther Nucleic Acids. 2012. PMID: 23344002 Free PMC article.

5

Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo.

Wada S, Obika S, Shibata MA, Yamamoto T, Nakatani M, Yamaoka T, Torigoe H, Harada-Shiba M. Wada S, et al. Mol Ther Nucleic Acids. 2012 Sep 18;1(9):e45. doi: 10.1038/mtna.2012.32. Mol Ther Nucleic Acids. 2012. PMID: 23344237 Free PMC article.

6

Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma.

Yamamoto T, Obika S, Nakatani M, Yasuhara H, Wada F, Shibata E, Shibata MA, Harada-Shiba M. Yamamoto T, et al. Eur J Pharmacol. 2014 Jan 15;723:353-9. doi: 10.1016/j.ejphar.2013.11.004. Epub 2013 Nov 20. Eur J Pharmacol. 2014. PMID: 24269597

7

Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.

Yamamoto T, Fujii N, Yasuhara H, Wada S, Wada F, Shigesada N, Harada-Shiba M, Obika S. Yamamoto T, et al. Nucleic Acid Ther. 2014 Aug;24(4):283-90. doi: 10.1089/nat.2013.0470. Epub 2014 Apr 23. Nucleic Acid Ther. 2014. PMID: 24758560 Free PMC article.

8

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.

Yamamoto T, Sawamura M, Wada F, Harada-Shiba M, Obika S. Yamamoto T, et al. Bioorg Med Chem. 2016 Jan 1;24(1):26-32. doi: 10.1016/j.bmc.2015.11.036. Epub 2015 Nov 27. Bioorg Med Chem. 2016. PMID: 26678173

9

Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides.

Wada S, Yasuhara H, Wada F, Sawamura M, Waki R, Yamamoto T, Harada-Shiba M, Obika S. Wada S, et al. J Control Release. 2016 Mar 28;226:57-65. doi: 10.1016/j.jconrel.2016.02.007. Epub 2016 Feb 5. J Control Release. 2016. PMID: 26855051

10

Development of Antisense Drugs for Dyslipidemia.

Yamamoto T, Wada F, Harada-Shiba M. Yamamoto T, et al. J Atheroscler Thromb. 2016 Sep 1;23(9):1011-25. doi: 10.5551/jat.RV16001. Epub 2016 Jul 27. J Atheroscler Thromb. 2016. PMID: 27466159 Free PMC article. Review.

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