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Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma.
Yamamoto T, Obika S, Nakatani M, Yasuhara H, Wada F, Shibata E, Shibata MA, Harada-Shiba M. Yamamoto T, et al. Among authors: yasuhara h. Eur J Pharmacol. 2014 Jan 15;723:353-9. doi: 10.1016/j.ejphar.2013.11.004. Epub 2013 Nov 20. Eur J Pharmacol. 2014. PMID: 24269597
Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice.
Yamamoto T, Harada-Shiba M, Nakatani M, Wada S, Yasuhara H, Narukawa K, Sasaki K, Shibata MA, Torigoe H, Yamaoka T, Imanishi T, Obika S. Yamamoto T, et al. Among authors: yasuhara h. Mol Ther Nucleic Acids. 2012 May 15;1(5):e22. doi: 10.1038/mtna.2012.16. Mol Ther Nucleic Acids. 2012. PMID: 23344002 Free PMC article.
DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing.
Nishina K, Piao W, Yoshida-Tanaka K, Sujino Y, Nishina T, Yamamoto T, Nitta K, Yoshioka K, Kuwahara H, Yasuhara H, Baba T, Ono F, Miyata K, Miyake K, Seth PP, Low A, Yoshida M, Bennett CF, Kataoka K, Mizusawa H, Obika S, Yokota T. Nishina K, et al. Among authors: yasuhara h. Nat Commun. 2015 Aug 10;6:7969. doi: 10.1038/ncomms8969. Nat Commun. 2015. PMID: 26258894 Free PMC article.
294 results