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Pharmacological characterization of the novel γ-secretase modulator AS2715348, a potential therapy for Alzheimer's disease, in rodents and nonhuman primates.
Mitani Y, Akashiba H, Saita K, Yarimizu J, Uchino H, Okabe M, Asai M, Yamasaki S, Nozawa T, Ishikawa N, Shitaka Y, Ni K, Matsuoka N. Mitani Y, et al. Among authors: shitaka y. Neuropharmacology. 2014 Apr;79:412-9. doi: 10.1016/j.neuropharm.2013.12.013. Epub 2013 Dec 25. Neuropharmacology. 2014. PMID: 24373902
Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease.
Noda-Saita K, Terai K, Iwai A, Tsukamoto M, Shitaka Y, Kawabata S, Okada M, Yamaguchi T. Noda-Saita K, et al. Among authors: shitaka y. Acta Neuropathol. 2004 Nov;108(5):435-42. doi: 10.1007/s00401-004-0907-2. Epub 2004 Sep 14. Acta Neuropathol. 2004. PMID: 15372280
25 results