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Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Bellido T, et al. Among authors: manolagas sc. J Biol Chem. 2003 Dec 12;278(50):50259-72. doi: 10.1074/jbc.M307444200. Epub 2003 Oct 1. J Biol Chem. 2003. PMID: 14523023 Free article.
Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.
Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Vertino AM, et al. Among authors: manolagas sc. J Biol Chem. 2005 Apr 8;280(14):14130-7. doi: 10.1074/jbc.M410720200. Epub 2005 Jan 25. J Biol Chem. 2005. PMID: 15671029 Free article.
221 results