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Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices.
Koziol-White CJ, Jia Y, Baltus GA, Cooper PR, Zaller DM, Crackower MA, Sirkowski EE, Smock S, Northrup AB, Himes BE, Alves SE, Panettieri RA Jr. Koziol-White CJ, et al. Among authors: crackower ma. Br J Pharmacol. 2016 Nov;173(21):3080-3087. doi: 10.1111/bph.13550. Epub 2016 Oct 5. Br J Pharmacol. 2016. PMID: 27417329 Free PMC article.
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
St Pierre C, Guo J, Shin JD, Engstrom LW, Lee HH, Herbert A, Surdi L, Baker J, Salmon M, Shah S, Ellis JM, Houshyar H, Crackower MA, Kleinschek MA, Jones DC, Hicks A, Zaller DM, Alves SE, Ramadas RA. St Pierre C, et al. Among authors: crackower ma. PLoS One. 2017 Jul 18;12(7):e0180870. doi: 10.1371/journal.pone.0180870. eCollection 2017. PLoS One. 2017. PMID: 28719615 Free PMC article.
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. Wang IM, et al. Among authors: crackower ma. Mol Syst Biol. 2012 Jul 17;8:594. doi: 10.1038/msb.2012.24. Mol Syst Biol. 2012. PMID: 22806142 Free PMC article.
Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.
Moy LY, Jia Y, Caniga M, Lieber G, Gil M, Fernandez X, Sirkowski E, Miller R, Alexander JP, Lee HH, Shin JD, Ellis JM, Chen H, Wilhelm A, Yu H, Vincent S, Chapman RW, Kelly N, Hickey E, Abraham WM, Northrup A, Miller T, Houshyar H, Crackower MA. Moy LY, et al. Among authors: crackower ma. Am J Respir Cell Mol Biol. 2013 Dec;49(6):1085-92. doi: 10.1165/rcmb.2013-0200OC. Am J Respir Cell Mol Biol. 2013. PMID: 23889698
Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells.
Burton OT, Noval Rivas M, Zhou JS, Logsdon SL, Darling AR, Koleoglou KJ, Roers A, Houshyar H, Crackower MA, Chatila TA, Oettgen HC. Burton OT, et al. Among authors: crackower ma. Immunity. 2014 Jul 17;41(1):141-51. doi: 10.1016/j.immuni.2014.05.017. Epub 2014 Jul 10. Immunity. 2014. PMID: 25017467 Free PMC article.
Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer.
Wang IM, Stepaniants S, Boie Y, Mortimer JR, Kennedy B, Elliott M, Hayashi S, Loy L, Coulter S, Cervino S, Harris J, Thornton M, Raubertas R, Roberts C, Hogg JC, Crackower M, O'Neill G, Paré PD. Wang IM, et al. Am J Respir Crit Care Med. 2008 Feb 15;177(4):402-11. doi: 10.1164/rccm.200703-390OC. Epub 2007 Nov 1. Am J Respir Crit Care Med. 2008. PMID: 17975202
Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.
Bernier V, Stocco R, Bogusky MJ, Joyce JG, Parachoniak C, Grenier K, Arget M, Mathieu MC, O'Neill GP, Slipetz D, Crackower MA, Tan CM, Therien AG. Bernier V, et al. Among authors: crackower ma. J Biol Chem. 2006 Aug 25;281(34):24704-12. doi: 10.1074/jbc.M603691200. Epub 2006 Jun 20. J Biol Chem. 2006. PMID: 16790440 Free article.
Genes related to emphysema are enriched for ubiquitination pathways.
Stepaniants S, Wang IM, Boie Y, Mortimer J, Kennedy B, Elliott M, Hayashi S, Luo H, Wong J, Loy L, Coulter S, Roberts CJ, Hogg JC, Sin DD, O'Neill G, Crackower M, Morris M, Paré PD, Obeidat M. Stepaniants S, et al. Among authors: crackower m. BMC Pulm Med. 2014 Nov 29;14:187. doi: 10.1186/1471-2466-14-187. BMC Pulm Med. 2014. PMID: 25432663 Free PMC article.
47 results