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Characterization of binding mode of action of a blocking anti-platelet-derived growth factor (PDGF)-B monoclonal antibody, MOR8457, reveals conformational flexibility and avidity needed for PDGF-BB to bind PDGF receptor-β.
Kuai J, Mosyak L, Brooks J, Cain M, Carven GJ, Ogawa S, Ishino T, Tam M, Lavallie ER, Yang Z, Ponsel D, Rauchenberger R, Arch R, Pullen N. Kuai J, et al. Biochemistry. 2015 Mar 17;54(10):1918-29. doi: 10.1021/bi5015425. Epub 2015 Mar 6. Biochemistry. 2015. PMID: 25707433
Assays of ADP-ribosylation factor function.
Kuai J, Kahn RA. Kuai J, et al. Methods Enzymol. 2002;345:359-70. doi: 10.1016/s0076-6879(02)45029-x. Methods Enzymol. 2002. PMID: 11665619 No abstract available.
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.
Kuai J, Gregory B, Hill A, Pittman DD, Feldman JL, Brown T, Carito B, O'Toole M, Ramsey R, Adolfsson O, Shields KM, Dower K, Hall JP, Kurdi Y, Beech JT, Nanchahal J, Feldmann M, Foxwell BM, Brennan FM, Winkler DG, Lin LL. Kuai J, et al. Rheumatology (Oxford). 2009 Nov;48(11):1352-8. doi: 10.1093/rheumatology/kep235. Epub 2009 Aug 27. Rheumatology (Oxford). 2009. PMID: 19713442
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