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Page 1
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Pinto DJ, Smallheer JM, Corte JR, Austin EJ, Wang C, Fang T, Smith LM 2nd, Rossi KA, Rendina AR, Bozarth JM, Zhang G, Wei A, Ramamurthy V, Sheriff S, Myers JE Jr, Morin PE, Luettgen JM, Seiffert DA, Quan ML, Wexler RR. Pinto DJ, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1635-42. doi: 10.1016/j.bmcl.2015.01.028. Epub 2015 Feb 4. Bioorg Med Chem Lett. 2015. PMID: 25728130
Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile.
Fevig JM, Buriak J Jr, Cacciola J, Alexander RS, Kettner CA, Knabb RM, Pruitt JR, Weber PC, Wexler RR. Fevig JM, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1998 Feb 3;8(3):301-6. doi: 10.1016/s0960-894x(98)00013-4. Bioorg Med Chem Lett. 1998. PMID: 9871674
Orally active isoxazoline glycoprotein IIb/IIIa antagonists with extended duration of action.
Olson RE, Sielecki TM, Wityak J, Pinto DJ, Batt DG, Frietze WE, Liu J, Tobin AE, Orwat MJ, Di Meo SV, Houghton GC, Lalka GK, Mousa SA, Racanelli AL, Hausner EA, Kapil RP, Rabel SR, Thoolen MJ, Reilly TM, Anderson PS, Wexler RR. Olson RE, et al. Among authors: wexler rr. J Med Chem. 1999 Apr 8;42(7):1178-92. doi: 10.1021/jm980348t. J Med Chem. 1999. PMID: 10197962
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.
Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1999 Jul 29;42(15):2752-9. doi: 10.1021/jm980405i. J Med Chem. 1999. PMID: 10425086
196 results