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Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart.
Matsuhashi T, Hishiki T, Zhou H, Ono T, Kaneda R, Iso T, Yamaguchi A, Endo J, Katsumata Y, Atsushi A, Yamamoto T, Shirakawa K, Yan X, Shinmura K, Suematsu M, Fukuda K, Sano M. Matsuhashi T, et al. Among authors: atsushi a. J Mol Cell Cardiol. 2015 May;82:116-24. doi: 10.1016/j.yjmcc.2015.02.021. Epub 2015 Mar 2. J Mol Cell Cardiol. 2015. PMID: 25744081