Wang Y - Search Results

1

A ligand-based virtual screening approach to identify small molecules as HERG channel activators.

Giacomini E, Buonfiglio R, Masetti M, Wang Y, Tseng GN, Roberti M, Recanatini M. Giacomini E, et al. Among authors: wang y. Comb Chem High Throughput Screen. 2015;18(3):269-80. doi: 10.2174/1386207318666150305121841. Comb Chem High Throughput Screen. 2015. PMID: 25747449

2

Wang YH, Jiang M, Xu XL, Hsu KL, Zhang M, Tseng GN. Wang YH, et al. J Membr Biol. 2011 Feb;239(3):137-56. doi: 10.1007/s00232-010-9333-7. Epub 2010 Dec 9. J Membr Biol. 2011. PMID: 21152909 Free PMC article.

3

Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the I_Ks Amplitude in Check Until When Larger I_Ks Is Needed.

Jiang M, Wang Y, Tseng GN. Jiang M, et al. Among authors: wang y. Circ Arrhythm Electrophysiol. 2017 Jun;10(6):e005084. doi: 10.1161/CIRCEP.117.005084. Circ Arrhythm Electrophysiol. 2017. PMID: 28611207 Free PMC article.

4

Building KCNQ1/KCNE1 channel models and probing their interactions by molecular-dynamics simulations.

Xu Y, Wang Y, Meng XY, Zhang M, Jiang M, Cui M, Tseng GN. Xu Y, et al. Among authors: wang y. Biophys J. 2013 Dec 3;105(11):2461-73. doi: 10.1016/j.bpj.2013.09.058. Biophys J. 2013. PMID: 24314077 Free PMC article.

5

Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2.

Jiang M, Xu X, Wang Y, Toyoda F, Liu XS, Zhang M, Robinson RB, Tseng GN. Jiang M, et al. Among authors: wang y. J Biol Chem. 2009 Jun 12;284(24):16452-16462. doi: 10.1074/jbc.M808262200. Epub 2009 Apr 16. J Biol Chem. 2009. PMID: 19372218 Free PMC article.

6

Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.

Xu Y, Wang Y, Zhang M, Jiang M, Rosenhouse-Dantsker A, Wassenaar T, Tseng GN. Xu Y, et al. Among authors: wang y. Biophys J. 2015 Jan 6;108(1):62-75. doi: 10.1016/j.bpj.2014.10.059. Biophys J. 2015. PMID: 25564853 Free PMC article.

7

KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner.

Zhang M, Wang Y, Jiang M, Zankov DP, Chowdhury S, Kasirajan V, Tseng GN. Zhang M, et al. Among authors: wang y. Am J Physiol Heart Circ Physiol. 2012 Feb 15;302(4):H910-22. doi: 10.1152/ajpheart.00691.2011. Epub 2011 Dec 16. Am J Physiol Heart Circ Physiol. 2012. PMID: 22180649 Free PMC article.

8

[Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes.

Wang Y, Zankov DP, Jiang M, Zhang M, Henderson SC, Tseng GN. Wang Y, et al. J Biol Chem. 2013 Dec 6;288(49):35358-71. doi: 10.1074/jbc.M113.504746. Epub 2013 Oct 18. J Biol Chem. 2013. PMID: 24142691 Free PMC article.

9

Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model.

Xu X, Jiang M, Wang Y, Smith T, Baumgarten CM, Wood MA, Tseng GN. Xu X, et al. Among authors: wang y. PLoS One. 2010 Apr 13;5(4):e10140. doi: 10.1371/journal.pone.0010140. PLoS One. 2010. PMID: 20405051 Free PMC article.

10

Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2.

Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Wang Y, et al. J Gen Physiol. 2012 Dec;140(6):653-69. doi: 10.1085/jgp.201210847. J Gen Physiol. 2012. PMID: 23183700 Free PMC article.

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