Nguyen LH - Search Results

1

mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.

Nguyen LH, Brewster AL, Clark ME, Regnier-Golanov A, Sunnen CN, Patil VV, D'Arcangelo G, Anderson AE. Nguyen LH, et al. Epilepsia. 2015 Apr;56(4):636-46. doi: 10.1111/epi.12946. Epub 2015 Mar 6. Epilepsia. 2015. PMID: 25752454 Free PMC article.

2

mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy.

Nguyen LH, Anderson AE. Nguyen LH, et al. Sci Rep. 2018 Feb 23;8(1):3568. doi: 10.1038/s41598-018-21656-8. Sci Rep. 2018. PMID: 29476105 Free PMC article.

3

Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy.

Nguyen LH, Xu Y, Mahadeo T, Zhang L, Lin TV, Born HA, Anderson AE, Bordey A. Nguyen LH, et al. Brain. 2022 May 24;145(4):1310-1325. doi: 10.1093/brain/awab390. Brain. 2022. PMID: 34849602 Free PMC article.

4

mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia.

Nguyen LH, Mahadeo T, Bordey A. Nguyen LH, et al. J Neurosci. 2019 Apr 3;39(14):2762-2773. doi: 10.1523/JNEUROSCI.2260-18.2019. Epub 2019 Jan 30. J Neurosci. 2019. PMID: 30700531 Free PMC article.

5

Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations.

Zhang L, Huang T, Teaw S, Nguyen LH, Hsieh LS, Gong X, Burns LH, Bordey A. Zhang L, et al. Among authors: nguyen lh. Sci Transl Med. 2020 Feb 19;12(531):eaay0289. doi: 10.1126/scitranslmed.aay0289. Sci Transl Med. 2020. PMID: 32075941

6

Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice.

Hsieh LS, Wen JH, Nguyen LH, Zhang L, Getz SA, Torres-Reveron J, Wang Y, Spencer DD, Bordey A. Hsieh LS, et al. Among authors: nguyen lh. Sci Transl Med. 2020 Nov 18;12(570):eabc1492. doi: 10.1126/scitranslmed.abc1492. Sci Transl Med. 2020. PMID: 33208499 Free PMC article.

7

The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function.

Nguyen LH, Xu Y, Nair M, Bordey A. Nguyen LH, et al. Elife. 2024 Feb 27;12:RP91010. doi: 10.7554/eLife.91010. Elife. 2024. PMID: 38411613 Free PMC article.

8

The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function.

Nguyen LH, Xu Y, Nair M, Bordey A. Nguyen LH, et al. bioRxiv [Preprint]. 2024 Jan 6:2023.08.11.553034. doi: 10.1101/2023.08.11.553034. bioRxiv. 2024. Update in: Elife. 2024 Feb 27;12:RP91010. doi: 10.7554/eLife.91010 PMID: 37609221 Free PMC article. Updated. Preprint.

9

Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex.

Nguyen LH, Leiser SC, Song D, Brunner D, Roberds SL, Wong M, Bordey A. Nguyen LH, et al. Epilepsy Res. 2022 Mar;181:106890. doi: 10.1016/j.eplepsyres.2022.106890. Epub 2022 Feb 18. Epilepsy Res. 2022. PMID: 35219048 Free PMC article.

10

4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice.

Nguyen LH, Sharma M, Bordey A. Nguyen LH, et al. Front Neurosci. 2023 Aug 23;17:1257056. doi: 10.3389/fnins.2023.1257056. eCollection 2023. Front Neurosci. 2023. PMID: 37680968 Free PMC article.

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