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The Staphylococcus aureus ABC-Type Manganese Transporter MntABC Is Critical for Reinitiation of Bacterial Replication Following Exposure to Phagocytic Oxidative Burst.
Coady A, Xu M, Phung Q, Cheung TK, Bakalarski C, Alexander MK, Lehar SM, Kim J, Park S, Tan MW, Nishiyama M. Coady A, et al. Among authors: alexander mk. PLoS One. 2015 Sep 17;10(9):e0138350. doi: 10.1371/journal.pone.0138350. eCollection 2015. PLoS One. 2015. PMID: 26379037 Free PMC article.
A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria.
Nickerson NN, Jao CC, Xu Y, Quinn J, Skippington E, Alexander MK, Miu A, Skelton N, Hankins JV, Lopez MS, Koth CM, Rutherford S, Nishiyama M. Nickerson NN, et al. Among authors: alexander mk. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02151-17. doi: 10.1128/AAC.02151-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29339384 Free PMC article.
Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM. Ho H, et al. Among authors: alexander mk. Nature. 2018 May;557(7704):196-201. doi: 10.1038/s41586-018-0083-5. Epub 2018 May 2. Nature. 2018. PMID: 29720648
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA.
Alexander MK, Miu A, Oh A, Reichelt M, Ho H, Chalouni C, Labadie S, Wang L, Liang J, Nickerson NN, Hu H, Yu L, Du M, Yan D, Park S, Kim J, Xu M, Sellers BD, Purkey HE, Skelton NJ, Koehler MFT, Payandeh J, Verma V, Xu Y, Koth CM, Nishiyama M. Alexander MK, et al. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01142-18. doi: 10.1128/AAC.01142-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30104274 Free PMC article.
Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.
Verma VA, Wang L, Labadie SS, Liang J, Sellers BD, Wang J, Dong L, Wang Q, Zhang S, Xu Z, Zhang Y, Niu Y, Wang X, Wai J, Koehler MFT, Hu H, Alexander MK, Nishiyama M, Miu A, Xu Y, Pang J, Katakam AK, Reichelt M, Austin CD, Ho H, Payandeh J, Koth CM. Verma VA, et al. Among authors: alexander mk. J Med Chem. 2022 Mar 10;65(5):4085-4120. doi: 10.1021/acs.jmedchem.1c01909. Epub 2022 Feb 20. J Med Chem. 2022. PMID: 35184554
The discovery and structural basis of two distinct state-dependent inhibitors of BamA.
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J. Sun D, et al. Among authors: alexander mk. Nat Commun. 2024 Oct 8;15(1):8718. doi: 10.1038/s41467-024-52512-1. Nat Commun. 2024. PMID: 39379361 Free PMC article.
X chromosomes alternate between two states prior to random X-inactivation.
Mlynarczyk-Evans S, Royce-Tolland M, Alexander MK, Andersen AA, Kalantry S, Gribnau J, Panning B. Mlynarczyk-Evans S, et al. Among authors: alexander mk. PLoS Biol. 2006 Jun;4(6):e159. doi: 10.1371/journal.pbio.0040159. Epub 2006 May 9. PLoS Biol. 2006. PMID: 16669701 Free PMC article.
45 results