Stivers JT - Search Results

1

A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.

Seamon KJ, Stivers JT. Seamon KJ, et al. Among authors: stivers jt. J Biomol Screen. 2015 Jul;20(6):801-9. doi: 10.1177/1087057115575150. Epub 2015 Mar 9. J Biomol Screen. 2015. PMID: 25755265 Free PMC article.

2

Ribonuclease activity of vaccinia DNA topoisomerase IB: kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay.

Kwon K, Nagarajan R, Stivers JT. Kwon K, et al. Among authors: stivers jt. Biochemistry. 2004 Nov 30;43(47):14994-5004. doi: 10.1021/bi048801s. Biochemistry. 2004. PMID: 15554707

3

Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2.

Jiang YL, Chung S, Krosky DJ, Stivers JT. Jiang YL, et al. Among authors: stivers jt. Bioorg Med Chem. 2006 Aug 15;14(16):5666-72. doi: 10.1016/j.bmc.2006.04.022. Epub 2006 May 5. Bioorg Med Chem. 2006. PMID: 16678429

4

Fluorescence-based high-throughput assay for human DNA (cytosine-5)-methyltransferase 1.

Ye Y, Stivers JT. Ye Y, et al. Among authors: stivers jt. Anal Biochem. 2010 Jun 1;401(1):168-72. doi: 10.1016/j.ab.2010.02.032. Epub 2010 Mar 1. Anal Biochem. 2010. PMID: 20197058 Free PMC article.

5

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.

Hansen EC, Seamon KJ, Cravens SL, Stivers JT. Hansen EC, et al. Among authors: stivers jt. Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1843-51. doi: 10.1073/pnas.1401706111. Epub 2014 Apr 21. Proc Natl Acad Sci U S A. 2014. PMID: 24753578 Free PMC article.

6

Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

Seamon KJ, Hansen EC, Kadina AP, Kashemirov BA, McKenna CE, Bumpus NN, Stivers JT. Seamon KJ, et al. Among authors: stivers jt. J Am Chem Soc. 2014 Jul 16;136(28):9822-5. doi: 10.1021/ja5035717. Epub 2014 Jul 8. J Am Chem Soc. 2014. PMID: 24983818 Free PMC article.

7

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity.

Seamon KJ, Sun Z, Shlyakhtenko LS, Lyubchenko YL, Stivers JT. Seamon KJ, et al. Among authors: stivers jt. Nucleic Acids Res. 2015 Jul 27;43(13):6486-99. doi: 10.1093/nar/gkv633. Epub 2015 Jun 22. Nucleic Acids Res. 2015. PMID: 26101257 Free PMC article.

8

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.

Seamon KJ, Bumpus NN, Stivers JT. Seamon KJ, et al. Among authors: stivers jt. Biochemistry. 2016 Nov 8;55(44):6087-6099. doi: 10.1021/acs.biochem.6b00986. Epub 2016 Oct 27. Biochemistry. 2016. PMID: 27775344 Free PMC article.

9

Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.

Christenson ES, Gizzi A, Cui J, Egleston M, Seamon KJ, DePasquale M, Orris B, Park BH, Stivers JT. Christenson ES, et al. Among authors: stivers jt. Mol Pharmacol. 2021 Jun;99(6):412-425. doi: 10.1124/molpharm.120.000191. Epub 2021 Apr 1. Mol Pharmacol. 2021. PMID: 33795350 Free PMC article.

10

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics.

Orris B, Huynh KW, Ammirati M, Han S, Bolaños B, Carmody J, Petroski MD, Bosbach B, Shields DJ, Stivers JT. Orris B, et al. Among authors: stivers jt. Nucleic Acids Res. 2022 Jul 22;50(13):7545-7559. doi: 10.1093/nar/gkac573. Nucleic Acids Res. 2022. PMID: 35801923 Free PMC article.

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