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Page 1
Defining the mechanism of polymerization in the serpinopathies.
Ekeowa UI, Freeke J, Miranda E, Gooptu B, Bush MF, Pérez J, Teckman J, Robinson CV, Lomas DA. Ekeowa UI, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17146-51. doi: 10.1073/pnas.1004785107. Epub 2010 Sep 20. Proc Natl Acad Sci U S A. 2010. PMID: 20855577 Free PMC article.
α(1)-antitrypsin deficiency and inflammation.
Ekeowa UI, Marciniak SJ, Lomas DA. Ekeowa UI, et al. Expert Rev Clin Immunol. 2011 Mar;7(2):243-52. doi: 10.1586/eci.10.95. Expert Rev Clin Immunol. 2011. PMID: 21426261 Review.
Unravelling the twists and turns of the serpinopathies.
Roussel BD, Irving JA, Ekeowa UI, Belorgey D, Haq I, Ordóñez A, Kruppa AJ, Duvoix A, Rashid ST, Crowther DC, Marciniak SJ, Lomas DA. Roussel BD, et al. FEBS J. 2011 Oct;278(20):3859-67. doi: 10.1111/j.1742-4658.2011.08201.x. Epub 2011 Jun 20. FEBS J. 2011. PMID: 21624056 Free article. Review.
The serpinopathies studying serpin polymerization in vivo.
Irving JA, Ekeowa UI, Belorgey D, Haq I, Gooptu B, Miranda E, Pérez J, Roussel BD, Ordóñez A, Dalton LE, Thomas SE, Marciniak SJ, Parfrey H, Chilvers ER, Teckman JH, Alam S, Mahadeva R, Rashid ST, Vallier L, Lomas DA. Irving JA, et al. Methods Enzymol. 2011;501:421-66. doi: 10.1016/B978-0-12-385950-1.00018-3. Methods Enzymol. 2011. PMID: 22078544
Targeting serpins in high-throughput and structure-based drug design.
Chang YP, Mahadeva R, Patschull AO, Nobeli I, Ekeowa UI, McKay AR, Thalassinos K, Irving JA, Haq I, Nyon MP, Christodoulou J, Ordóñez A, Miranda E, Gooptu B. Chang YP, et al. Methods Enzymol. 2011;501:139-75. doi: 10.1016/B978-0-12-385950-1.00008-0. Methods Enzymol. 2011. PMID: 22078534
Characterisation of serpin polymers in vitro and in vivo.
Belorgey D, Irving JA, Ekeowa UI, Freeke J, Roussel BD, Miranda E, Pérez J, Robinson CV, Marciniak SJ, Crowther DC, Michel CH, Lomas DA. Belorgey D, et al. Methods. 2011 Mar;53(3):255-66. doi: 10.1016/j.ymeth.2010.11.008. Epub 2010 Nov 27. Methods. 2011. PMID: 21115126 Review.
28 results